Learning to see again: biological constraints on cortical plasticity and the implications for sight restoration technologies.
Learning to see again: biological constraints on cortical plasticity and the implications for sight restoration technologies.
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DOI：
10.1088/1741-2552/aa795e
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发表时间：
2017-10
影响因子：
4
通讯作者：
Fine I
中科院分区：
文献类型：
--
作者：
Beyeler M;Rokem A;Boynton GM;Fine I
“仿生眼”--长久以来的未来梦想--终于成为现实，美国和欧洲的患者都可以使用视网膜假体。然而，这些植入物的临床经验表明，这些器械提供的视力与正常视力有很大不同。因此，学习利用这种异常视网膜输入的能力在是否成功恢复某些功能性视力方面起着关键作用。本综述的目的是总结大量的基础科学文献的发展和成人皮质可塑性，重点是如何将这一文献可能涉及到领域的假体视觉。我们开始描述的失真和信息丢失可能会经历的视觉假体用户。然后，我们定义了皮层可塑性和知觉学习，并描述了什么是已知的，什么是未知的，关于视觉可塑性的大脑区域参与视觉处理的层次结构，并在不同的生命阶段。最后，我们讨论了视力恢复患者的大脑可塑性，并讨论了最终可能被利用来改善这些患者视觉学习的生物学机制。
The “bionic eye” – so long a dream of the future – is finally becoming a reality with retinal prostheses available to patients in both the US and Europe. However, clinical experience with these implants has made it apparent that the vision provided by these devices differs substantially from normal sight. Consequently, the ability to learn to make use of this abnormal retinal input plays a critical role in whether or not some functional vision is successfully regained. The goal of the present review is to summarize the vast basic science literature on developmental and adult cortical plasticity with an emphasis on how this literature might relate to the field of prosthetic vision. We begin with describing the distortion and information loss likely to be experienced by visual prosthesis users. We then define cortical plasticity and perceptual learning, and describe what is known, and what is unknown, about visual plasticity across the hierarchy of brain regions involved in visual processing, and across different stages of life. We close by discussing what is known about brain plasticity in sight restoration patients and discuss biological mechanisms that might eventually be harnessed to improve visual learning in these patients.
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影响因子：
5.7
作者：
Ackman JB;Crair MC
通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
Hochstein, S
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通讯作者：
Fine, Ione
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作者：
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通讯作者：
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64.8
作者：
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通讯作者：
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