Renal Prognosis and Related Risk Factors for Henoch-Schönlein Purpura Nephritis: A Chinese Adult Patient Cohort.
Renal Prognosis and Related Risk Factors for Henoch-Schönlein Purpura Nephritis: A Chinese Adult Patient Cohort.
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过敏性紫癜肾炎的肾脏预后和相关危险因素：中国成年患者队列
DOI：
10.1038/s41598-018-23638-2
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发表时间：
2018-04-03
影响因子：
4.6
通讯作者：
Tang Z
中科院分区：
文献类型：
--
作者：
Huang X;Wu X;Le W;Hao Y;Wu J;Zeng C;Liu Z;Tang Z
本研究探讨了中国成人过敏性紫癜性肾炎（HSPN）的临床病理特征，并分析了其肾脏结局和进展为终末期肾病（ESRD）的预后危险因素。研究了经活检证实的HSPN成人患者。分析其临床病理资料、肾脏病变及相关危险因素。共研究了698例患者，包括363例男性（52.0%）和335例女性（48.0%）。血尿和蛋白尿多见（85.8%和82.1%）。在中位随访54.0个月期间，32例患者（4.6%）进展为ESRD。ESRD的5年和10年累积肾存活率分别为96.4%和88.6%。基线尿蛋白、肾功能不全、肾小球硬化和肾小管萎缩/间质纤维化是肾脏结局的独立预测因素。随访期间的平均动脉压和蛋白尿也影响肾脏预后。时间平均蛋白尿<0.4 g/d的患者ESRD发生率最低，肾功能下降50%。总之，识别临床和组织学预后因素可能有助于预测肾脏预后。HSPN患者的最佳治疗目标可能是将蛋白尿降至<0.4 g/d，并控制高血压，以获得理想的肾脏结局。
This study investigated the clinicopathological characteristics of Henoch-Schönlein purpura nephritis (HSPN) in Chinese adult patients and analyzed the renal outcomes and prognostic risk factors for progression to end-stage renal disease (ESRD). Adult patients who had biopsy-proven HSPN were studied. Their clinicopathological data, renal prognoses and related risk factors were assessed. A total of 698 patients were studied, including 363 men (52.0%) and 335 women (48.0%). Most of the patients had hematuria (85.8%) and/or proteinuria (82.1%). During a median follow-up of 54.0 months, 32 patients (4.6%) progressed to ESRD. The 5- and 10-year cumulative renal survival rates from ESRD were 96.4% and 88.6%, respectively. Baseline urinary protein, renal insufficiency, glomerular sclerosis and tubular atrophy/interstitial fibrosis were independent predictors of renal outcomes. Both the time-average mean arterial pressure and proteinuria during follow-up also influenced the renal prognosis. The patients with a time-average proteinuria <0.4 g/day had the lowest rates of ESRD or a 50% decline in renal function. In conclusion, identifying of clinical and histological prognostic factors may permit the prediction of renal outcomes. The optimal goal of therapy for HSPN patients may be to lower proteinuria to <0.4 g/day and control hypertension to achieve an ideal renal outcome.
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影响因子：
1.7
作者：
Ghrahani R;Ledika MA;Sapartini G;Setiabudiawan B
通讯作者：
Setiabudiawan B
影响因子：
1.6
作者：
Calvo-Río V;Loricera J;Mata C;Martín L;Ortiz-Sanjuán F;Alvarez L;González-Vela MC;González-Lamuño D;Rueda-Gotor J;Fernández-Llaca H;González-López MA;Armesto S;Peiró E;Arias M;González-Gay MA;Blanco R
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Blanco R
影响因子：
3
作者：
Schärer, K;Krmar, R;Schafer, F
通讯作者：
Schafer, F
DOI：
10.1097/01.asn.0000013883.99976.22
发表时间：
2002-05-01
影响因子：
13.6
作者：
Pillebout, E;Thervet, E;Nochy, D
通讯作者：
Nochy, D
影响因子：
13.3
作者：
Shrestha, S;Sumingan, N;Ballardie, F
通讯作者：
Ballardie, F