Lead exposure increases blood pressure by increasing angiotensinogen expression
Lead exposure increases blood pressure by increasing angiotensinogen expression
复制标题
铅暴露通过增加血管紧张素原的表达来增加血压
DOI：
10.1080/10934529.2015.1120537
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
李春平
中科院分区：
文献类型：
--
作者：
王苗苗;王宜庆;孙纳;李春平
铅暴露可引起血压升高。已经提出了几种机制来解释铅引起的高血压。血管紧张素原（AGT）表达水平或基因变异的变化也可能影响血压。在这项研究中，我们假设AGT表达水平或基因变异有助于铅诱导的高血压。进行初步的HEK293细胞模型实验以分析AGT表达与铅暴露之间的关联。在一项以人群为基础的研究中，在铅暴露人群和对照人群中测量血清AGT水平。为进一步探讨AGT基因单核苷酸多态性（single nucleotide polymorphisms，SNPs）在铅致高血压中的作用，采用病例对照研究方法，对219名铅暴露者和393名对照者进行了AGT基因rs699和rs4762的基因分型。铅暴露导致HEK 293细胞模型中AGT表达水平增加（P < 0.001），铅暴露个体的收缩压和舒张压升高（P < 0.001）。铅暴露组血清AGT水平高于对照组（P < 0.001）。AGT基因rs699和rs4762单核苷酸多态性与铅暴露无相关性。然而，AGT表达水平的变化可能在铅性高血压的发生发展中起重要作用。
ABSTRACT Lead exposure can induce increased blood pressure. Several mechanisms have been proposed to explain lead-induced hypertension. Changes in angiotensinogen (AGT) expression levels or gene variants may also influence blood pressure. In this study, we hypothesized that AGT expression levels or gene variants contribute to lead-induced hypertension. A preliminary HEK293 cell model experiment was performed to analyze the association between AGT expression and lead exposure. In a population-based study, serum AGT level was measured in both lead-exposed and control populations. To further detect the influence of AGT gene single nucleotide polymorphisms (SNPs) in lead-induced hypertension, two SNPs (rs699 and rs4762) were genotyped in a case-control study including 219 lead-exposed subjects and 393 controls. Lead exposure caused an increase in AGT expression level in HEK 293 cell models (P < 0.001) compared to lead-free cells, and individuals exposed to lead had higher systolic and diastolic blood pressure (P < 0.001). Lead-exposed individuals had higher serum AGT levels compared to controls (P < 0.001). However, no association was found between AGT gene SNPs (rs699 and rs4762) and lead exposure. Nevertheless, the change in AGT expression level may play an important role in the development of lead-induced hypertension.
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影响因子：
3.1
作者：
J. Yugar-Toledo;J. F. Martin;J. Krieger;A. Pereira;Caroline Demacq;O. Coelho;E. Pimenta;D. Calhoun;H. M. Júnior
通讯作者：
J. Yugar-Toledo;J. F. Martin;J. Krieger;A. Pereira;Caroline Demacq;O. Coelho;E. Pimenta;D. Calhoun;H. M. Júnior
DOI：
10.1161/hypertensionaha.111.00770
发表时间：
2013-04
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Galis ZS;Thrasher T;Reid DM;Stanley DV;Oh YS
通讯作者：
Oh YS
影响因子：
3.7
作者：
Simões MR;Ribeiro Júnior RF;Vescovi MV;de Jesus HC;Padilha AS;Stefanon I;Vassallo DV;Salaices M;Fioresi M
通讯作者：
Fioresi M
成人铅毒性的流行病学：测量剂量和考虑其他方法论问题。
影响因子：
10.4
作者：
Hu, Howard;Shih, Regina;Rothenberg, Stephen;Schwartz, Brian S.
通讯作者：
Schwartz, Brian S.
影响因子：
3.2
作者：
Chunping Li;Xiaolin Yang;Ming Xu;Jinlong Zhang;N. Sun
通讯作者：
Chunping Li;Xiaolin Yang;Ming Xu;Jinlong Zhang;N. Sun