SR proteins in vertical integration of gene expression from transcription to RNA processing to translation.
SR proteins in vertical integration of gene expression from transcription to RNA processing to translation.
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DOI：
10.1016/j.molcel.2009.06.016
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发表时间：
2009-07-10
期刊：
影响因子：
16
通讯作者：
Fu, Xiang-Dong
中科院分区：
文献类型：
--
作者：
Zhong, Xiang-Yang;Wang, Pingping;Han, Joonhee;Rosenfeld, Michael G.;Fu, Xiang-Dong
SR蛋白作为一个RNA结合蛋白家族，在哺乳动物细胞中参与组成性和调节性前mRNA剪接，已被广泛研究。然而，SR蛋白首先被发现作为与转录活性染色质相互作用的因子。最近的研究已经发现了连接这些曾经明显不同的功能的特性，表明SR蛋白的一个子集似乎直接与组蛋白3尾部结合，在转录延伸中发挥积极作用，并与参与特定的染色体内和染色体间相互作用的基因共定位，以协调调节细胞核中的基因表达。这些转录相关的活动也与特定SR蛋白家族成员在mRNA剪接下游的RNA代谢中的推定功能的进一步扩展相结合，从RNA输出到稳定性控制再到翻译。因此，这些发现突出了SR蛋白在基因表达的垂直整合中的更广泛的作用，并提供了对它们在高等真核细胞中对基因组稳定性和适当的细胞周期进展的贡献的机制见解。
SR proteins have been studied extensively as a family of RNA binding proteins that participate in both constitutive and regulated pre-mRNA splicing in mammalian cells. However, SR proteins were first discovered as factors that interact with transcriptionally active chromatin. Recent studies have now uncovered properties that connect these once apparently disparate functions, showing that a subset of SR proteins seem to bind directly to the histone 3 tail, play an active role in transcriptional elongation, and co-localize with genes that are engaged in specific intra- and inter-chromosome interactions for coordinated regulation of gene expression in the nucleus. These transcription-related activities are also coupled with a further expansion of putative functions of specific SR protein family members in RNA metabolism downstream of mRNA splicing, from RNA export to stability control to translation. These findings therefore highlight the broader roles of SR proteins in vertical integration of gene expression and provide mechanistic insights into their contributions to genome stability and proper cell cycle progression in higher eukaryotic cells.
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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期刊：
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通讯作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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