A mixture approach to investigate interstitial growth in engineering scaffolds.
A mixture approach to investigate interstitial growth in engineering scaffolds.
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DOI：
10.1007/s10237-015-0684-y
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发表时间：
2016-04
影响因子：
3.5
通讯作者：
Vernerey FJ
中科院分区：
文献类型：
--
作者：
Vernerey FJ
控制充满细胞的聚合物支架内的生物生长是组织工程界的一个关键挑战。事实上，构建体的生长通常必须与支架降解相平衡，并且常常与因膨胀、外力和限制效应引起的不同程度的变形相结合。这些因素已被证明会以多种方式影响增长，但迄今为止，我们的理解大多是定性的。虽然细胞传感、分子运输和支架/组织相互作用被认为是重要的参与者，但量化、预测和控制这些影响对于最终优化实验室中的组织生长至关重要。因此，本文的目的是提供一个理论框架，以更好地理解支架介导的运输、沉积（以及可能的降解）和弹性机制如何影响受到有限变形的组织的整体生长。我们提出了一种公式，通过考虑三个基本原理：机械平衡、化学平衡和分子不可压缩性，组织尺寸、密度以及残余应力的出现的宏观演变可以与内部成分的变化直接相关。由此产生的模型使我们能够特别关注对生长和变形之间相互作用至关重要的特征：渗透压和膨胀、旧沉积材料和新沉积材料之间的应变不匹配以及机械敏感细胞介导的生产。我们表明，所有这些现象确实可能强烈影响有限变形下结构的整体生长。
Controlling biological growth within a cell-laden polymeric scaffold is a critical challenge in the tissue engineering community. Indeed, construct growth must often be balanced with scaffold degradation and is often coupled to varying degrees of deformation that originate from swelling, external forces and the effects of confinement. These factors have been shown to affect growth in many ways, but to date, our understanding is mostly qualitative. While cell sensing, molecular transport and scaffold/tissue interactions are believed to be important players, it will be critical to quantify, predict and control these effects in order to eventually optimize tissue growth in the laboratory. The aim of this paper is thus to provide a theoretical framework, to better understand how the scaffold-mediated mechanisms of transport, deposition (and possibly degradation) and elasticity affect the overall growth of a tissue subjected to finite deformations. We propose a formulation in which the macroscopic evolutions in tissue size, density as well as the appearance of residual stresses can be directly related to changes in internal composition by considering three fundamental principles: mechanical equilibrium, chemical equilibrium and molecular incompressibility. The resulting model allows us to pay particular attention to features that are critical to the interaction between growth and deformation: osmotic pressure and swelling, the strain mismatch between old and newly deposited material as well as the mechano-sensitive cell-mediated production. We show that all of these phenomena may indeed strongly affect the overall growth of a construct under finite deformations.
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影响因子：
6.2
作者：
Park, Hansoo;Guo, Xuan;Temenoff, Johnna S.;Tabata, Yasuhiko;Caplan, Arnold I.;Kasper, F. Kurtis;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.
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通讯作者：
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影响因子：
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作者：
Ateshian, Gerard A.;Ricken, Tim
通讯作者：
Ricken, Tim