Can the causal role of brain oscillations be studied through rhythmic brain stimulation?
Can the causal role of brain oscillations be studied through rhythmic brain stimulation?
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DOI：
10.1167/jov.21.12.2
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发表时间：
2021-11-01
影响因子：
1.8
通讯作者：
Bauer M
中科院分区：
文献类型：
--
作者：
Lobo T;Brookes MJ;Bauer M
许多研究已经调查了使用有节奏刺激的大脑振荡的因果关系，无论是通过直接的大脑刺激还是通过感觉刺激。然而，内在节奏如何与外部产生的节奏相互作用在很大程度上是未知的。在脑磁图同步记录人类的心理物理变化检测任务中，我们提出了闪烁（60 Hz）视觉光栅或相应的无闪烁刺激，以测试视觉夹带对诱发伽马振荡的影响。值得注意的是，我们普遍观察到宽带诱导的伽马节律与携带的闪烁节律共存（在每个参与者中都可靠地测量到了），而诱导响应的峰值频率在大约一半的参与者中保持不变——相对独立于他们的固有频率。然而，闪烁增加了宽带诱导的伽马功率，这在固有频率更接近闪烁频率（共振）的参与者中更强，并导致强烈的相位携带。闪烁的存在并没有改变行为本身，但深刻地改变了整个样本的大脑行为：虽然宽带诱导的伽马振荡与无闪烁刺激的反应时间相关（如前所述），但对于闪烁，携带的闪烁节律的振幅（但不再是诱导振荡）与反应时间相关。然而，这在很大程度上取决于参与者的峰值频率是否转移到伴随节奏上。我们的研究结果表明，有节奏的脑刺激导致两种部分独立的振荡共存，这些振荡在参与者中对这些节律对行为的下游相关性有异质影响。这可能解释了与大脑振荡的外部夹带相关的发现的不一致性，并对大脑振荡的因果操纵提出了进一步的问题。
Many studies have investigated the causal relevance of brain oscillations using rhythmic stimulation, either through direct-brain or sensory stimulation. Yet, how intrinsic rhythms interact with the externally generated rhythm is largely unknown. We presented a flickered (60 Hz) visual grating or its correspondent unflickered stimulus in a psychophysical change detection task during simultaneous magnetoencephalography recordings to humans to test the effect of visual entrainment on induced gamma oscillations. Notably, we generally observed the coexistence of the broadband induced gamma rhythm with the entrained flicker rhythm (reliably measured in each participant), with the peak frequency of the induced response remaining unaltered in approximately half of participants—relatively independently of their native frequency. However, flicker increased broadband induced gamma power, and this was stronger in participants with a native frequency closer to the flicker frequency (resonance) and led to strong phase entrainment. Presence of flicker did not change behavior itself but profoundly altered brain behavior correlates across the sample: While broadband induced gamma oscillations correlated with reaction times for unflickered stimuli (as known previously), for the flicker, the amplitude of the entrained flicker rhythm (but no more the induced oscillation) correlated with reaction times. This, however, strongly depended on whether a participant's peak frequency shifted to the entrained rhythm. Our results suggests that rhythmic brain stimulation leads to a coexistence of two partially independent oscillations with heterogeneous effects across participants on the downstream relevance of these rhythms for behavior. This may explain the inconsistency of findings related to external entrainment of brain oscillations and poses further questions toward causal manipulations of brain oscillations in general.
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影响因子：
9.2
作者：
Bauer, Markus;Kluge, Christian;Bach, Dominik;Bradbury, David;Heinze, Hans Jochen;Dolan, Raymond J.;Driver, Jon
通讯作者：
Driver, Jon
DOI：
10.1073/pnas.1011284108
发表时间：
2011-07-05
影响因子：
11.1
作者：
Buffalo, Elizabeth A.;Fries, Pascal;Desimone, Robert
通讯作者：
Desimone, Robert
DOI：
10.1523/jneurosci.3134-20.2021
发表时间：
2021-08-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Duecker K;Gutteling TP;Herrmann CS;Jensen O
通讯作者：
Jensen O
影响因子：
3.4
作者：
Mitra, PP;Pesaran, B
通讯作者：
Pesaran, B
影响因子：
1.8
作者：
Bauer, Markus;Akam, Thomas;Driver, Jon
通讯作者：
Driver, Jon