Role of the extracellular matrix in COVID-19.
Role of the extracellular matrix in COVID-19.
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DOI：
10.12998/wjcc.v11.i1.73
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发表时间：
2023-01-06
影响因子：
1.1
通讯作者：
Qian, Guo-Qing
中科院分区：
文献类型：
--
作者：
Huang, Jia-Jia;Wang, Chu-Wen;Liu, Ying;Zhang, Ying-Ying;Yang, Nai-Bin;Yu, Yu-Chun;Jiang, Qi;Song, Qi-Fa;Qian, Guo-Qing
2019年冠状病毒病(新冠肺炎)的爆发已蔓延至全球，迄今已有5亿多例病例和600多万人死亡。新冠肺炎与全身炎症反应和细胞外基质异常有关，后者也参与了炎症风暴。在病毒感染后，ECM蛋白参与炎症细胞的募集和干扰靶器官的代谢，包括在肺部。此外，细胞外基质周转的血清生物标志物与新冠肺炎的严重程度相关，可能成为潜在的靶点。因此，了解细胞外基质的表达和功能，尤其是肺细胞外基质在严重急性呼吸综合征期间的表达和功能，将为深入了解新冠肺炎的进展机制提供有价值的见解。在这篇综述中，我们总结了目前关于细胞外基质的研究结果，如透明质酸、基质金属蛋白酶和胶原，它们与新冠肺炎的严重程度和炎症有关。一些针对细胞外表面的药物已经有效。未来，这些细胞外基质的发现可能为新冠肺炎的发病机制和治疗提供新的视角。
An outbreak of coronavirus disease 2019 (COVID-19) has spread globally, with over 500 million cases and 6 million deaths to date. COVID-19 is associated with a systemic inflammatory response and abnormalities of the extracellular matrix (ECM), which is also involved in inflammatory storms. Upon viral infection, ECM proteins are involved in the recruitment of inflammatory cells and interference with target organ metabolism, including in the lungs. Additionally, serum biomarkers of ECM turnover are associated with the severity of COVID-19 and may serve as potential targets. Consequently, understanding the expression and function of ECM, particularly of the lung, during severe acute respiratory syndrome of the coronavirus 2 infection would provide valuable insights into the mechanisms of COVID-19 progression. In this review, we summarize the current findings on ECM, such as hyaluronic acid, matrix metalloproteinases, and collagen, which are linked to the severity and inflammation of COVID-19. Some drugs targeting the extracellular surface have been effective. In the future, these ECM findings could provide novel perspectives on the pathogenesis and treatment of COVID-19.
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DOI：
10.1056/nejmoa2119451
发表时间：
2022-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Andrews N;Stowe J;Kirsebom F;Toffa S;Rickeard T;Gallagher E;Gower C;Kall M;Groves N;O'Connell AM;Simons D;Blomquist PB;Zaidi A;Nash S;Iwani Binti Abdul Aziz N;Thelwall S;Dabrera G;Myers R;Amirthalingam G;Gharbia S;Barrett JC;Elson R;Ladhani SN;Ferguson N;Zambon M;Campbell CNJ;Brown K;Hopkins S;Chand M;Ramsay M;Lopez Bernal J
通讯作者：
Lopez Bernal J
影响因子：
13.6
作者：
Jung，Sascha;Potapov，Ilya;del Sol，Antonio
通讯作者：
del Sol，Antonio
影响因子：
4.7
作者：
Allawadhi P;Singh V;Khurana I;Rawat PS;Renushe AP;Khurana A;Navik U;Allwadhi S;Kumar Karlapudi S;Banothu AK;Bharani KK
通讯作者：
Bharani KK
胶原蛋白沉积在COVID-19中的扩展和计算机断层扫描分析发现。
影响因子：
5.6
作者：
Ball L;Barisione E;Mastracci L;Campora M;Costa D;Robba C;Battaglini D;Micali M;Costantino F;Cittadini G;Patroniti N;Pelosi P;Fiocca R;Grillo F
通讯作者：
Grillo F
DOI：
10.1016/j.biopha.2021.112067
发表时间：
2021-10
期刊：
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
影响因子：
--
作者：
D Avila-Mesquita C;Couto AES;Campos LCB;Vasconcelos TF;Michelon-Barbosa J;Corsi CAC;Mestriner F;Petroski-Moraes BC;Garbellini-Diab MJ;Couto DMS;Jordani MC;Ferro D;Sbragia L;Joviliano EE;Evora PR;Carvalho Santana R;Martins-Filho OA;Polonis K;Menegueti MG;Ribeiro MS;Auxiliadora-Martins M;Becari C
通讯作者：
Becari C