Repurposing Anthelmintics: Rafoxanide- and Copper-Functionalized SBA-15 Carriers against Methicillin-Resistant Staphylococcus aureus.
Repurposing Anthelmintics: Rafoxanide- and Copper-Functionalized SBA-15 Carriers against Methicillin-Resistant Staphylococcus aureus.
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DOI：
10.1021/acsami.2c19899
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发表时间：
2023-04-12
影响因子：
9.5
通讯作者：
Asefa, Tewodros
中科院分区：
文献类型：
--
作者：
Ramirez-Hernandez, Maricely;Norambuena, Javiera;Hu, Hongnan;Thomas, Belvin;Tang, Chaoyun;Boyd, Jeffrey M.;Asefa, Tewodros
The development of materials that can more efficiently administer antimicrobial agents in a controlled manner is urgently needed due to the rise in microbial resistance to traditional antibiotics. While new classes of antibiotics are developed and put into widespread usage, existing, inexpensive compounds can be repurposed to fight bacterial infections. Here we present the synthesis of amine-functionalized SBA-15 mesoporous silica nanomaterials with physisorbed rafoxanide (RFX), a commonly used salicylanilide anthelmintic, and anchored Cu(II) ions that exhibit enhanced antimicrobial efficacy against the pathogenic bacterium Staphylococcus aureus. The synthesized nanomaterials are structurally characterized by a combination of physicochemical, thermal, and optical methods. Additionally, release studies are carried out in vitro to determine the effects of pH and the synthetic sequence used to produce the materials on Cu(II) ion release. Our results indicate that SBA-15 mesoporous silica nanocarriers loaded with Cu(II) and RFX exhibit ten times as much bactericidal action against wild-type Staphylococcus aureus as the nanocarrier loaded with only RFX. Furthermore, the synthetic sequence used to produce the nanomaterials could significantly affect (enhance) their bactericidal efficacy.
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影响因子：
3.9
作者：
通讯作者：
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毒品重新利用的驱虫药：机遇和挑战。
DOI：
10.1016/j.jsps.2021.04.004
发表时间：
2021-05
期刊：
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
影响因子：
--
作者：
Alavi SE;Ebrahimi Shahmabadi H
通讯作者：
Ebrahimi Shahmabadi H
影响因子：
6.7
作者：
Bhattacharyya J;Ren XR;Mook RA;Wang J;Spasojevic I;Premont RT;Li X;Chilkoti A;Chen W
通讯作者：
Chen W
影响因子：
64.5
作者：
Chen DH;Madan D;Weaver J;Lin Z;Schröder GF;Chiu W;Rye HS
通讯作者：
Rye HS
影响因子：
3.6
作者：
Al-Tameemi H;Beavers WN;Norambuena J;Skaar EP;Boyd JM
通讯作者：
Boyd JM