Prospective study of the association between sport-related concussion and brain morphometry (3T-MRI) in collegiate athletes: study from the NCAA-DoD CARE Consortium.
Prospective study of the association between sport-related concussion and brain morphometry (3T-MRI) in collegiate athletes: study from the NCAA-DoD CARE Consortium.
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大学运动员运动相关脑震荡与脑形态测量 (3T-MRI) 之间关联的前瞻性研究：NCAA-DoD CARE 联盟的研究。
DOI：
10.1136/bjsports-2020-102002
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发表时间：
2021-03
影响因子：
18.4
通讯作者：
CARE Consortium Investigators
中科院分区：
文献类型：
--
作者：
Bobholz SA;Brett BL;España LY;Huber DL;Mayer AR;Harezlak J;Broglio SP;McAllister T;McCrea MA;Meier TB;CARE Consortium Investigators
确定大学接触性运动员运动相关脑震荡与皮质下和皮质结构的急性和早期长期关联。近期有运动相关脑震荡的运动员（N=99）和匹配的接触（N=91）和非接触运动对照（N=95）在受伤后24-48小时至6个月内完成了最多4次神经影像学检查。使用FreeSurfer计算皮质下体积（杏仁核、海马、丘脑、背侧纹状体）和皮质厚度/体积的顶点方向测量值。线性混合效应模型检查脑震荡和结构指标之间的急性和纵向关联，控制颅内体积（或平均厚度）和人口统计学变量（包括既往脑震荡和运动暴露）。在各次访视中，杏仁核体积存在显著的组依赖性变化（p=0.041）;这种效应是由6个月时相对于接触对照组的亚急性访视，杏仁核体积增加的趋势驱动的，在运动相关脑震荡的运动员中没有差异。在任何皮质度量中均未观察到差异（即，厚度或体积）用于主要或次要分析。在6个月的时间范围内，单一的运动相关脑震荡与灰质结构的关联最小。
To determine the acute and early long-term associations of sport-related concussion and subcortical and cortical structures in collegiate contact sport athletes. Athletes with a recent sport-related concussion (N=99) and matched contact (N=91) and non-contact sport controls (N=95) completed up to four neuroimaging sessions from 24–48 hours to 6 months post-injury. Subcortical volumes (amygdala, hippocampus, thalamus, dorsal striatum) and vertex-wise measurements of cortical thickness/volume were computed using FreeSurfer. Linear mixed-effects models examined the acute and longitudinal associations between concussion and structural metrics, controlling for intracranial volume (or mean thickness) and demographic variables (including prior concussions and sport exposure). There were significant group-dependent changes in amygdala volumes across visits (p=0.041); this effect was driven by a trend for increased amygdalae volume at 6-months relative to sub-acute visits in contact controls, with no differences in athletes with sport-related concussion. No differences were observed in any cortical metric (i.e., thickness or volume) for primary or secondary analyses. A single sport-related concussion had minimal associations with gray matter structure across a 6-month time frame.
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DOI：
10.1007/s40279-017-0707-1
发表时间：
2017-07
期刊：
Sports medicine (Auckland, N.Z.)
影响因子：
--
作者：
Broglio SP;McCrea M;McAllister T;Harezlak J;Katz B;Hack D;Hainline B;CARE Consortium Investigators
通讯作者：
CARE Consortium Investigators
影响因子：
--
作者：
Chen, Jen-Kai;Johnston, Karen M.;Ptito, Alain
通讯作者：
Ptito, Alain
影响因子：
4.8
作者：
Guskiewicz, KM;Marshall, SW;Jordan, BD
通讯作者：
Jordan, BD
影响因子：
2.7
作者：
Benjamini, Yoav;Krieger, Abba M.;Yekutieli, Daniel
通讯作者：
Yekutieli, Daniel
影响因子：
1.9
作者：
Hellstrom, T.;Westlye, L. T.;Andelic, N.
通讯作者：
Andelic, N.