Pancreatic Cancer Related Health Disparities: A Commentary.
Pancreatic Cancer Related Health Disparities: A Commentary.
复制标题
胰腺癌相关的健康差异：评论。
DOI：
10.3390/cancers10070235
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发表时间：
2018-07-18
期刊：
影响因子：
5.2
通讯作者：
Wilkie DJ
中科院分区：
文献类型：
--
作者：
Scarton L;Yoon S;Oh S;Agyare E;Trevino J;Han B;Lee E;Setiawan VW;Permuth JB;Schmittgen TD;Odedina FG;Wilkie DJ
我们总结了可能显著导致胰腺癌种族差异的风险因素，胰腺癌现在是癌症死亡的第三大原因，预计在12年内将在2030年左右成为第二大原因。几十年来，黑人胰腺癌的发病率比美国其他种族高30%至70%，5年生存率约为5%。糖尿病和肥胖已被确定为胰腺癌的潜在诱发因素，两者在黑人中更常见。吸烟仍然是胰腺癌最重要的危险因素之一，黑人的吸烟率高于其他种族群体。由于DNA的变化，胰腺癌的总体风险被认为对大多数种族群体是相同的;然而，DNA甲基化水平在黑人和白人之间有显着差异。这一发现可能是胰腺癌种族差异的基础。识别和预防这些因素可能是降低黑人胰腺癌高发病率和死亡率的有效策略。
We summarize the risk factors that may significantly contribute to racial disparities in pancreatic cancer, which is now the third leading cause of cancer deaths and projected to be second around 2030 in 12 years. For decades, the incidence rate of pancreatic cancer among Blacks has been 30% to 70% higher than other racial groups in the United States and the 5-year survival rate is approximately 5%. Diabetes and obesity have been identified as potentially predisposing factors to pancreatic cancer and both are more common among Blacks. Smoking continues to be one of the most important risk factors for pancreatic cancer and smoking rates are higher among Blacks compared to other racial groups. The overall risk of pancreatic cancer due to changes in DNA is thought to be the same for most racial groups; however, DNA methylation levels have been observed to be significantly different between Blacks and Whites. This finding may underlie the racial disparities in pancreatic cancer. Identification and prevention of these factors may be effective strategies to reduce the high incidence and mortality rates for pancreatic cancer among Blacks.
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影响因子：
4
作者：
Brotherton, Lindsay;Welton, Michael;Robb, Sara W.
通讯作者：
Robb, Sara W.
影响因子：
5.8
作者：
Costello LC;Franklin RB
通讯作者：
Franklin RB
DOI：
10.1016/s0140-6736(17)33326-3
发表时间：
2018-03-17
期刊：
Lancet (London, England)
影响因子：
--
作者：
Allemani C;Matsuda T;Di Carlo V;Harewood R;Matz M;Nikšić M;Bonaventure A;Valkov M;Johnson CJ;Estève J;Ogunbiyi OJ;Azevedo E Silva G;Chen WQ;Eser S;Engholm G;Stiller CA;Monnereau A;Woods RR;Visser O;Lim GH;Aitken J;Weir HK;Coleman MP;CONCORD Working Group
通讯作者：
CONCORD Working Group
影响因子：
4.5
作者：
Engelken J;Carnero-Montoro E;Pybus M;Andrews GK;Lalueza-Fox C;Comas D;Sekler I;de la Rasilla M;Rosas A;Stoneking M;Valverde MA;Vicente R;Bosch E
通讯作者：
Bosch E
影响因子：
3.8
作者：
DeLancey, John Oliver L.;Thun, Michael J.;Ward, Elizabeth M.
通讯作者：
Ward, Elizabeth M.