The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques.
The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques.
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DOI：
10.1084/jem.188.6.1159
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发表时间：
1998-09-21
期刊：
影响因子：
--
通讯作者：
Sodroski J
中科院分区：
文献类型：
--
作者：
Karlsson GB;Halloran M;Schenten D;Lee J;Racz P;Tenner-Racz K;Manola J;Gelman R;Etemad-Moghadam B;Desjardins E;Wyatt R;Gerard NP;Marcon L;Margolin D;Fanton J;Axthelm MK;Letvin NL;Sodroski J
人类免疫缺陷病毒1型（HIV-1）感染者的CD 4 + T淋巴细胞耗竭是获得性免疫缺陷综合征发生的基础。使用一个模型，其中恒河猴感染嵌合猴-人类免疫缺陷病毒（SHIV），我们表明，病毒血症的水平和HIV-1包膜糖蛋白胞外域的结构单独贡献的效率与CD 4 + T淋巴细胞被耗尽。与致病性较低的病毒相比，重组SHIV的包膜糖蛋白有效地引起CD 4 + T淋巴细胞的损失，表现出增加的趋化因子受体结合和膜融合能力。这些研究确定HIV-1包膜糖蛋白胞外域是体内CD 4 + T淋巴细胞丢失的决定因素，并为研究致病机制提供了基础。
CD4+ T lymphocyte depletion in human immunodeficiency virus type 1 (HIV-1)–infected humans underlies the development of acquired immune deficiency syndrome. Using a model in which rhesus macaques were infected with chimeric simian–human immunodeficiency viruses (SHIVs), we show that both the level of viremia and the structure of the HIV-1 envelope glycoprotein ectodomains individually contributed to the efficiency with which CD4+ T lymphocytes were depleted. The envelope glycoproteins of recombinant SHIVs that efficiently caused loss of CD4+ T lymphocytes exhibited increased chemokine receptor binding and membrane-fusing capacity compared with those of less pathogenic viruses. These studies identify the HIV-1 envelope glycoprotein ectodomains as determinants of CD4+ T lymphocyte loss in vivo and provide a foundation for studying pathogenic mechanisms.
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