Effects of 3,5-Diiodotyrosine and Potassium Iodide on Thyroid Function and Oxidative Stress in Iodine-Excess Wistar Rats
Effects of 3,5-Diiodotyrosine and Potassium Iodide on Thyroid Function and Oxidative Stress in Iodine-Excess Wistar Rats
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3,5-二碘酪氨酸和碘化钾对碘过量 Wistar 大鼠甲状腺功能和氧化应激的影响
DOI：
10.1007/s12011-015-0371-y
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发表时间：
2015-05
影响因子：
3.9
通讯作者：
Wang Xia
中科院分区：
文献类型：
--
作者：
Liu Dan;Lin Xinying;Yu Fugui;Zhang Man;Chen Hongxia;Bao Wei;Wang Xia
本研究旨在探讨有机碘（3，5-diiodotyrosine，DIT）和无机碘（碘化钾，KI）对高碘Wistar大鼠甲状腺功能和氧化应激的影响。将72只Wistar大鼠随机分为8组：正常对照组（NC）、甲亢模型组（HM）、低碘组（L-DIT）、中碘组（M-DIT）、高碘组（H-DIT）、低碘组（L-KI）、中碘组（M-KI）、高碘组（H-KI）。所有大鼠自由采食30天。测量甲状腺的形态学变化、甲状腺的绝对和相对重量、甲状腺功能标志物游离三碘甲状腺原氨酸（FT 3）和游离甲状腺素（FT 4）、尿碘水平和氧化应激指标。与HM组相比，L-DIT组FT 3和FT 4水平降低; L-DIT和M-DIT组甲状腺重量和甲状腺重量/体重值显著降低;血清超氧化物歧化酶/丙二醛显著升高; L-DIT组谷胱甘肽过氧化物酶活性显著升高; M-DIT组丙二醛水平显著降低。然而，与相应的KI组相比，DIT组的FT 3和FT 4水平降低，谷胱甘肽过氧化物酶水平显著升高。此外，尿碘水平在DIT和KI组中均显著增加，但尿碘排泄量在组间以DIT组最高。在高碘大鼠中添加相同剂量的碘时，尽管DIT和KI均不能使高碘大鼠的碘水平正常化，但DIT对甲状腺滤泡细胞的损伤小于KI。因此，当暴露于超生理碘时，DIT而不是KI通过平衡抗氧化系统具有保护作用。因此，在全民食盐加碘的过程中，可将DIT作为一种新的替代碘盐，以避免过量KI的潜在危害。
The objective of this study was to investigate the effects of organic iodine (3,5-diiodotyrosine, DIT) and inorganic iodine (potassium iodine, KI) on thyroid function and oxidative stress in iodine-excess Wistar rats. Seventy-two Wistar rats were randomly divided into eight groups: normal control (NC), thyroid tablet-induced hyperthyroidism model (HM), low DIT (L-DIT), medium DIT (M-DIT), high DIT (H-DIT), low KI (L-KI), medium KI (M-KI), and high KI (H-KI). All rats were fed ad libitum for 30 days. Morphological changes in the thyroid, absolute and relative weights of the thyroid, thyroid function markers free triiodothyronine (FT3) and free thyroxine (FT4), urinary iodine level, and oxidative stress indicators were measured. Compared to the HM groups, the FT3 and FT4 levels decreased in the L-DIT groups; the thyroid weight and thyroid weight/body weight values decreased markedly in the L-DIT and M-DIT groups; serum superoxide dismutase/malondialdehyde increased markedly; glutathione peroxidase activity increased markedly in the L-DIT groups; and malondialdehyde levels decreased significantly in the M-DIT groups. However, the FT3 and FT4 levels decreased and glutathione peroxidase levels increased significantly in the DIT groups compared to their corresponding KI groups. Additionally, urinary iodine levels increased significantly in both DIT and KI groups, while the highest urinary iodine excretion was showed in the DIT groups among groups. When the addition of iodine with the same doses in iodine-excess rats, although neither DIT nor KI normalized iodine levels in the iodine-excess rats, the DIT did less damage than did KI to thyroid follicular cells. Therefore, DIT rather than KI had a protective effect by balancing the antioxidant system when exposed to supraphysiological iodine. These suggest that DIT may be used as a new alternative iodized salt in the universal salt iodization to avoid the potential damage of surplus KI.
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影响因子：
3.9
作者：
Yun Xia;W. Qu;Li-na Zhao;Hao Han;Xuefeng Yang;Xiu F Sun;Li-ping Hao;Jian Xu
通讯作者：
Yun Xia;W. Qu;Li-na Zhao;Hao Han;Xuefeng Yang;Xiu F Sun;Li-ping Hao;Jian Xu
影响因子：
3.6
作者：
Kumar, Narendra;Kar, Anand;Panda, Sunanda
通讯作者：
Panda, Sunanda
影响因子：
4.4
作者：
M. Vanderpump
通讯作者：
M. Vanderpump
影响因子：
10.4
作者：
Glatt CM;Ouyang M;Welsh W;Green JW;Connor JO;Frame SR;Everds NE;Poindexter G;Snajdr S;Delker DA
通讯作者：
Delker DA
影响因子：
4.1
作者：
Araujo, ASR;Ribeiro, MFM;Belló-Klein, A
通讯作者：
Belló-Klein, A