GOLPH3 regulates the migration and invasion of glioma cells though RhoA.
GOLPH3 regulates the migration and invasion of glioma cells though RhoA.
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GOLPH3通过RhoA调节胶质瘤细胞的迁移和侵袭。
DOI：
10.1016/j.bbrc.2013.03.003
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发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Yu R
中科院分区：
文献类型：
--
作者：
Li Y;Zhang X;Liu G;Yu R
高尔基体磷蛋白3（Golgi phosphoprotein 3，GOLPH 3）与多种人类肿瘤的发生发展有关。然而，GOLPH3在胶质瘤进展中的生物学意义在很大程度上仍然未知。在这项研究中，我们首次报道了GOLPH3的下调导致胶质瘤细胞迁移和侵袭的明显减少。此外，GOLPH3的下调抑制了小GT3 RhoA的表达以及细胞骨架重组，这两者都是胶质瘤细胞迁移所必需的。此外，我们发现所观察到的胶质瘤细胞迁移和RhoA水平的降低可以通过RhoA过表达来挽救。综上所述，这些结果表明GOLPH3通过调节RhoA的表达而有助于胶质瘤细胞的运动。
Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. However, the biological significance of GOLPH3 in glioma progression remains largely unknown. In this study, we report, for the first time, that downregulation of GOLPH3 led to clear reductions in glioma cell migration and invasion. In addition, downregulation of GOLPH3 inhibited the expression of the small GTPase RhoA as well as cytoskeletal reorganization, which are both required for glioma cell migration. Furthermore, we found that the observed reductions in glioma cell migration and RhoA level could be rescued by RhoA overexpression. Taken together, these results show that GOLPH3 contributes to the motility of glioma cells by regulating the expression of RhoA.
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影响因子：
3.9
作者：
Zhou, Jinxu;Xu, Tao;Chen, Juxiang
通讯作者：
Chen, Juxiang
影响因子：
56.9
作者：
Tu, Linna;Tai, William C. S.;Banfield, David K.
通讯作者：
Banfield, David K.
DOI：
10.1083/jcb.148.2.253
发表时间：
2000-01-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
O'Connor KL;Nguyen BK;Mercurio AM
通讯作者：
Mercurio AM
影响因子：
64.8
作者：
Scott, Kenneth L.;Kabbarah, Omar;Liang, Mei-Chih;Ivanova, Elena;Anagnostou, Valsamo;Wu, Joyce;Dhakal, Sabin;Wu, Min;Chen, Shujuan;Feinberg, Tamar;Huang, Joseph;Saci, Abdel;Widlund, Hans R.;Fisher, David E.;Xiao, Yonghong;Rimm, David L.;Protopopov, Alexei;Wong, Kwok-Kin;Chin, Lynda
通讯作者：
Chin, Lynda
GOLPH3 过表达与临床 N0 口腔舌癌患者的肿瘤进展和不良预后相关
影响因子：
7.4
作者：
Li H;Guo L;Chen SW;Zhao XH;Zhuang SM;Wang LP;Song LB;Song M
通讯作者：
Song M