Immune correlates of HIV-1 reservoir cell decline in early-treated infants.
Immune correlates of HIV-1 reservoir cell decline in early-treated infants.
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DOI：
10.1016/j.celrep.2022.111126
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发表时间：
2022-07-19
期刊：
影响因子：
8.8
通讯作者：
Lichterfeld, Mathias
中科院分区：
文献类型：
--
作者：
Hartana, Ciputra Adijaya;Garcia-Broncano, Pilar;Rassadkina, Yelizaveta;Lian, Xiaodong;Jiang, Chenyang;Einkauf, Kevin B.;Maswabi, Kenneth;Ajibola, Gbolahan;Moyo, Sikhulile;Mohammed, Terence;Maphorisa, Comfort;Makhema, Joseph;Yuki, Yuko;Martin, Maureen;Bennett, Kara;Jean-Philippe, Patrick;Viard, Mathias;Hughes, Michael D.;Powis, Kathleen M.;Carrington, Mary;Lockman, Shahin;Gao, Ce;Yu, Xu G.;Kuritzkes, Daniel R.;Shapiro, Roger;Lichterfeld, Mathias
Initiation of antiretroviral therapy (ART) in infected neonates within hours after birth limits viral reservoir seeding but does not prevent long-term HIV-1 persistence. Here, we report parallel assessments of HIV-1 reservoir cells and innate antiviral immune responses in a unique cohort of 37 infected neonates from Botswana who started ART extremely early, frequently within hours after birth. Decline of genome-intact HIV-1 proviruses occurs rapidly after initiation of ART and is associated with an increase in natural killer (NK) cell populations expressing the cytotoxicity marker CD57 and with a decrease in NK cell subsets expressing the inhibitory marker NKG2A. Immune perturbations in innate lymphoid cells, myeloid dendritic cells, and monocytes detected at birth normalize after rapid institution of antiretroviral therapy but do not notably influence HIV-1 reservoir cell dynamics. These results suggest that HIV-1 reservoir cell seeding and evolution in early-treated neonates is markedly influenced by antiviral NK cell immune responses. ART initiation in neonates leads to a profound decline of intact HIV-1 proviruses The longitudinal decline of intact HIV-1 proviruses is linked to NK cell responses Initiation of ART in neonates corrects innate immune perturbations in ILCs and DCs ILCs, macrophages, and DCs are not associated with a decline of intact HIV-1 proviruses Hartana et al. report longitudinal assessments of HIV-1 reservoir cells and innate immune responses in 37 infected neonates from Botswana who started antiretroviral treatment (ART) early, frequently within hours after birth. They observe that longitudinal decline of intact HIV-1 proviruses during ART is associated with antiviral NK cell immune responses.
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影响因子：
3.3
作者：
Ebrahimi D;Anwar F;Davenport MP
通讯作者：
Davenport MP
NKG2A 与 CD94 复合定义了一种新型抑制性自然杀伤细胞受体。
DOI：
10.1084/jem.185.4.795
发表时间：
1997-02-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Brooks AG;Posch PE;Scorzelli CJ;Borrego F;Coligan JE
通讯作者：
Coligan JE
影响因子：
6.4
作者：
Falcinelli, Shane D.;Kilpatrick, Kayla W.;Archin, Nancie M.
通讯作者：
Archin, Nancie M.
影响因子：
15.9
作者：
Lee, Guinevere Q.;Orlova-Fink, Nina;Lichterfeld, Mathias
通讯作者：
Lichterfeld, Mathias
影响因子：
16.6
作者：
Lee, Guinevere Q.;Reddy, Kavidha;Lichterfeld, Mathias
通讯作者：
Lichterfeld, Mathias