Intracerebroventricular interleukin-1 alpha increases immunocyte beta-endorphin concentrations in the rat: involvement of corticotropin-releasing hormone, catecholamines, and serotonin.
Intracerebroventricular interleukin-1 alpha increases immunocyte beta-endorphin concentrations in the rat: involvement of corticotropin-releasing hormone, catecholamines, and serotonin.
复制标题
脑室内白细胞介素 1 α 增加大鼠免疫细胞 β-内啡肽浓度：促肾上腺皮质激素释放激素、儿茶酚胺和血清素的参与。
作者：
P. Sacerdote;M. Bianchi;B. Manfredi;A. Panerai
阿片肽β-内啡肽 (BE) 由免疫系统细胞合成和分泌，已被证明参与免疫反应的调节，例如免疫反应。在压力期间。白细胞介素-1 (IL-1) 是下丘脑促肾上腺皮质激素释放激素 (CRH) 系统的有效激活剂，已被证明参与许多应激反应，包括免疫抑制。我们研究了集中注射 IL-1 α 对大鼠免疫细胞 BE 浓度的影响。 IL-1 α（1 ng/大鼠，脑室内）在治疗后 2 小时和 24 小时显着（P < 0.01）增加了脾细胞、淋巴结细胞和外周血单核细胞中肽的浓度。脑室内（而非静脉注射）施用 2 微克 IL-1 受体拮抗剂可阻断 IL-1 α 诱导的增加。脑室内给予 CRH 受体拮抗剂 α-螺旋 CRH-(9-41) 也可以预防这些效应。 6-羟基多巴胺和5,7-二羟基色胺治疗分别消耗儿茶酚胺能或血清素能系统，阻止细胞因子诱导的BE增加。相比之下，垂体切除术和吲哚美辛治疗并没有改变 IL 的效果。因此，免疫细胞BE的增加似乎取决于CRH、儿茶酚胺和血清素的激活，但与下丘脑-垂体-肾上腺轴和前列腺素的激活无关。免疫细胞BE的增加可能与中枢IL-1α诱导的免疫抑制有关。
The opioid peptide beta-endorphin (BE) is synthesized and secreted by the cells of the immune system and has been shown to participate in the modulation of immune responses, e.g. during stress. Interleukin-1 (IL-1) is a potent activator of the corticotropin-releasing hormone (CRH) system in the hypothalamus, and it has been shown to be involved in many stress responses, including immunosuppression. We studied the effect of centrally injected IL-1 alpha on immunocyte BE concentrations in the rat. IL-1 alpha (1 ng/rat, intracerebroventricularly) significantly (P < 0.01) increased the concentrations of the peptide in splenocytes, lymph node cells, and peripheral blood mononuclear cells 2 and 24 h after treatment. Intracerebroventricular, but not iv, administration of 2 micrograms IL-1 receptor antagonist blocked the IL-1 alpha-induced increase. These effects were also prevented by the intracerebroventricular administration of the CRH receptor antagonist alpha-helical CRH-(9-41). Treatment with 6-hydroxydopamine and 5,7-dihydroxytryptamine, which deplete the catecholaminergic or the serotoninergic systems, respectively, blocked the increase in BE induced by the cytokine. In contrast, hypophysectomy and treatment with indomethacin did not modify the effect of IL. The increase in immunocyte BE, therefore, seems to depend on the activation of CRH, catecholamines, and serotonin, but to be independent of activation of the hypothalamus-pituitary-adrenal-axis and prostaglandins. The immunocyte BE increase could be involved in the immunosuppression induced by central IL-1 alpha.
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大鼠脑室内注射重组人白细胞介素-1 诱导促肾上腺皮质激素释放：前列腺素可能参与。
影响因子：
4.8
作者：
Katsuura,G;Gottschall,PE;Dahl,RR;Arimura,A
通讯作者：
Arimura,A
影响因子：
56.9
作者：
SAPOLSKY, R;RIVIER, C;VALE, W
通讯作者：
VALE, W
下丘脑的去甲肾上腺素能神经支配参与肾上腺皮质对白介素-1 的反应。
影响因子：
4.1
作者：
Chuluyan,HE;Saphier,D;Rohn,WM;Dunn,AJ
通讯作者：
Dunn,AJ
影响因子：
4.8
作者：
I. Kakucska;Yanping Qi;B. D. Clark;R. Lechan
通讯作者：
I. Kakucska;Yanping Qi;B. D. Clark;R. Lechan