Evidence for causal top-down frontal contributions to predictive processes in speech perception.
Evidence for causal top-down frontal contributions to predictive processes in speech perception.
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DOI：
10.1038/s41467-017-01958-7
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发表时间：
2017-12-18
影响因子：
16.6
通讯作者：
Rowe JB
中科院分区：
文献类型：
--
作者：
Cope TE;Sohoglu E;Sedley W;Patterson K;Jones PS;Wiggins J;Dawson C;Grube M;Carlyon RP;Griffiths TD;Davis MH;Rowe JB
感知依赖于感官信息和先前预期的整合。在这里，我们表明人类额叶言语区选择性神经变性导致颞叶皮层预测的延迟和解。这些颞区没有萎缩，显示出正常的诱发磁和电，并保留了对感觉细节操作的神经敏感性。额叶神经退行性变并不妨碍上下文信息的感知效应；相反，先前的期望被僵化地应用。与预测编码的神经实例化理论模型一致，预测的精度与beta功率相关。当参与者用退化的感觉信号调和先前的预测时，额颞叶的相互作用增强了。过于精确的预测可以解释额叶失语症中的一些具有挑战性的现象，包括语法障碍和言语感知的主观困难。这项工作表明，认知和行为灵活性的高级额叶机制对语音感知的分层生成模型有因果作用。额叶在言语感知中的作用是有争议的。在这里，作者表明，额叶语言区域的神经退行性变延迟了颞叶皮层的预测调和，并导致不灵活的先前预期，表明额叶-颞叶相互作用决定了语言的预测过程。
Perception relies on the integration of sensory information and prior expectations. Here we show that selective neurodegeneration of human frontal speech regions results in delayed reconciliation of predictions in temporal cortex. These temporal regions were not atrophic, displayed normal evoked magnetic and electrical power, and preserved neural sensitivity to manipulations of sensory detail. Frontal neurodegeneration does not prevent the perceptual effects of contextual information; instead, prior expectations are applied inflexibly. The precision of predictions correlates with beta power, in line with theoretical models of the neural instantiation of predictive coding. Fronto-temporal interactions are enhanced while participants reconcile prior predictions with degraded sensory signals. Excessively precise predictions can explain several challenging phenomena in frontal aphasias, including agrammatism and subjective difficulties with speech perception. This work demonstrates that higher-level frontal mechanisms for cognitive and behavioural flexibility make a causal functional contribution to the hierarchical generative models underlying speech perception. The role of frontal lobes in speech perception is controversial. Here, the authors show that neurodegeneration of frontal speech regions delays prediction reconciliation in temporal cortex and results in inflexible prior expectations, indicating that fronto-temporal interactions determine predictive processes in speech.
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影响因子：
16.2
作者：
Bastos AM;Usrey WM;Adams RA;Mangun GR;Fries P;Friston KJ
通讯作者：
Friston KJ
影响因子：
3.4
作者：
Altmann, GTM;Kamide, Y
通讯作者：
Kamide, Y
DOI：
10.1098/rstb.2005.1622
发表时间：
2005-04-29
影响因子：
6.3
作者：
Friston, KJ
通讯作者：
Friston, KJ
影响因子：
5.3
作者：
Alink, Arjen;Schwiedrzik, Caspar M.;Muckli, Lars
通讯作者：
Muckli, Lars
影响因子：
16.6
作者：
Fontolan, L.;Morillon, B.;Liegeois-Chauvel, C.;Giraud, Anne-Lise
通讯作者：
Giraud, Anne-Lise