Inter-individual and inter-strain variations in zebrafish locomotor ontogeny.

Inter-individual and inter-strain variations in zebrafish locomotor ontogeny.
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DOI:
10.1371/journal.pone.0070172
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发表时间:
2013
期刊:
影响因子:
3.7
通讯作者:
Norton WH
Norton WH
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Lange M;Neuzeret F;Fabreges B;Froc C;Bedu S;Bally-Cuif L;Norton WH

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斑马鱼表现出显着的行为和形态的变化,因为它们从早期幼虫阶段发展到成熟的成年人。在这项研究中,我们比较了六个常见的斑马鱼品系从两个不同的实验室的运动参数,以确定这些行为的稳定性和可重复性。我们的研究结果表明,在运动和快速游泳事件之间的应变和实验室之间的跨时间的大的变化。这些数据强调了在分析运动表型时仔细的、菌株特异性控制的必要性,并开辟了在多个生命阶段标准化量化斑马鱼行为的可能性。
Zebrafish exhibit remarkable alterations in behaviour and morphology as they develop from early larval stages to mature adults. In this study we compare the locomotion parameters of six common zebrafish strains from two different laboratories to determine the stability and repeatability of these behaviours. Our results demonstrate large variability in locomotion and fast swim events between strains and between laboratories across time. These data highlight the necessity for careful, strain-specific controls when analysing locomotor phenotypes and open up the possibility of standardising the quantification of zebrafish behaviour at multiple life stages.
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