Continuous shifts in the active set of spinal interneurons during changes in locomotor speed.
Continuous shifts in the active set of spinal interneurons during changes in locomotor speed.
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DOI：
10.1038/nn.2225
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发表时间：
2008-12
影响因子：
25
通讯作者：
Fetcho, Joseph R.
中科院分区：
文献类型：
--
作者：
McLean, David L.;Masino, Mark A.;Koh, Ingrid Y. Y.;Lindquist, W. Brent;Fetcho, Joseph R.
经典的“大小原则”的运动控制描述了如何越来越有力的运动所产生的招聘运动神经元的逐步更大的尺寸和力量输出到活动池。在这里，我们探讨池的活动，脊髓中间神经元在幼斑马鱼，并发现游泳速度的增加是不相关的简单添加细胞的活动池。相反，中间神经元以更快的速度募集伴随着那些以较慢速度驱动运动的沉默。这种沉默发生在节律活跃的运动前兴奋性中间神经元之间和内部。因此，与运动神经元不同的是，尽管运动模式的运动速度和频率的变化看起来是平滑分级的，但驱动行为的细胞组中存在连续的变化。我们的结论是，从根本上不同的原则可能是运动神经元和中间神经元池的招聘。
The classic ‘size principle’ of motor control describes how increasingly forceful movements arise by the recruitment of motoneurons of progressively larger size and force output into the active pool. Here, we explore the activity of pools of spinal interneurons in larval zebrafish and find that increases in swimming speed are not associated with the simple addition of cells to the active pool. Instead, the recruitment of interneurons at faster speeds is accompanied by the silencing of those driving movements at slower speeds. This silencing occurs both between and within classes of rhythmically-active premotor excitatory interneurons. Thus, unlike motoneurons, there is a continuous shift in the set of cells driving the behavior, even though changes in the speed of the movements and the frequency of the motor pattern appear smoothly graded. We conclude that fundamentally different principles may underlie the recruitment of motoneuron and interneuron pools.
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影响因子：
2.5
作者：
HENNEMAN, E;SOMJEN, G;CARPENTER, DO
通讯作者：
CARPENTER, DO
影响因子：
2.5
作者：
Higashijima, S;Schaefer, M;Fetcho, JR
通讯作者：
Fetcho, JR
影响因子：
5.3
作者：
Li, Wen-Chang;Sautois, Bart;Soffe, Stephen R.
通讯作者：
Soffe, Stephen R.
影响因子：
2.5
作者：
FETCHO, JR
通讯作者：
FETCHO, JR
DOI：
10.1002/neu.10237
发表时间：
2003-09-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Gabriel, JP;Scharstein, H;Büschges, A
通讯作者：
Büschges, A