Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging.
Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging.
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DOI：
10.1016/j.biomaterials.2015.01.006
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发表时间：
2015-04
期刊：
影响因子：
14
通讯作者：
Gong, Shaoqin
中科院分区：
文献类型：
--
作者：
Chen, Guojun;Wang, Liwei;Cordie, Travis;Vokoun, Corinne;Eliceiri, Kevin W.;Gong, Shaoqin
关键词：
设计、合成并表征了由多臂星型两亲嵌段共聚物Boltron®H40 （H40，第四代超支化聚合物）-可生物降解光致发光聚合物(BPLP)-聚乙二醇（PEG）偶联cRGD肽（即H40-BPLP-PEG-cRGD）形成的新型自荧光单分子胶束纳米颗粒（NP）。疏水BPLP片段自荧光，从而使单分子胶团NP自荧光。cRGD肽可以有效靶向表达αvβ3整合素的肿瘤新生血管和肿瘤细胞，并选择性地偶联到胶束表面，提供活性肿瘤靶向能力。这种独特的自荧光单分子胶束表现出优异的光稳定性和低细胞毒性，使其成为一种有吸引力的生物成像探针，用于各种显微镜技术，包括荧光显微镜、共聚焦激光扫描显微镜（CLSM）和双光子显微镜。此外，这种自荧光单分子胶束NP由于其共价性质、高载药水平、ph控制的药物释放以及被动和主动的肿瘤靶向能力，在水溶液中也表现出了优异的稳定性，从而使其成为一种有前景的靶向癌症治疗的纳米平台。
A novel type of self-fluorescent unimolecular micelle nanoparticle (NP) formed by multi-arm star amphiphilic block copolymer, Boltron® H40 (H40, a 4th generation hyperbranched polymer)-biodegradable photo-luminescent polymer (BPLP)-poly(ethylene glycol) (PEG) conjugated with cRGD peptide (i.e., H40-BPLP-PEG-cRGD) was designed, synthesized, and characterized. The hydrophobic BPLP segment was self-fluorescent, thereby making the unimolecular micelle NP self-fluorescent. cRGD peptides, which can effectively target αvβ3 integrin-expressing tumor neovasculature and tumor cells, were selectively conjugated onto the surface of the micelles to offer active tumor-targeting ability. This unique self-fluorescent unimolecular micelle exhibited excellent photostability and low cytotoxicity, making it an attractive bioimaging probe for NP tracking for a variety of microscopy techniques including fluorescent microscopy, confocal laser scanning microscopy (CLSM), and two-photon microscopy. Moreover, this self-fluorescent unimolecular micelle NP also demonstrated excellent stability in aqueous solutions due to its covalent nature, high drug loading level, pH-controlled drug release, and passive and active tumor-targeting abilities, thereby making it a promising nanoplatform for targeted cancer theranostics.
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影响因子：
14
作者：
Guo, Jintang;Hong, Hao;Chen, Guojun;Shi, Sixiang;Zheng, Qifeng;Zhang, Yin;Theuer, Charles P.;Barnhart, Todd E.;Cai, Weibo;Gong, Shaoqin
通讯作者：
Gong, Shaoqin
影响因子：
29.4
作者：
Park, Ji-Ho;von Maltzahn, Geoffrey;Ong, Luvena L.;Centrone, Andrea;Hatton, T. Alan;Ruoslahti, Erkki;Bhatia, Sangeeta N.;Sailor, Michael J.
通讯作者：
Sailor, Michael J.
影响因子：
2.4
作者：
Lee, Yong-Kyu;Hong, Suk Min;Huh, Kang Moo
通讯作者：
Huh, Kang Moo
基于两亲性多臂星形嵌段共聚物的多功能单分子胶束，用于癌症靶向药物输送和磁共振成像
影响因子：
14
作者：
Li, Xiaojie;Qian, Yinfeng;Liu, Shiyong
通讯作者：
Liu, Shiyong
影响因子：
10
作者：
Gyawali, Dipendra;Zhou, Shengyuan;Tran, Richard T.;Zhang, Yi;Liu, Chao;Bai, Xiaochun;Yang, Jian
通讯作者：
Yang, Jian