Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery.
Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery.
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DOI：
10.1002/adma.200902895
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发表时间：
2010-02-23
影响因子：
29.4
通讯作者：
Sailor, Michael J.
中科院分区：
文献类型：
--
作者：
Park, Ji-Ho;von Maltzahn, Geoffrey;Ong, Luvena L.;Centrone, Andrea;Hatton, T. Alan;Ruoslahti, Erkki;Bhatia, Sangeeta N.;Sailor, Michael J.
一种结构类型执行多种医学诊断或治疗功能的能力通常被引用为纳米材料的有利特性，这是有机小分子无法实现的。[1-3]尽管现在有许多将多种功能集成到单个结构中的纳米系统的例子，但由于微小平台中的空间和表面化学限制，这些设计可能会降低单个功能的功效。例如，磁性纳米颗粒和药物分子可以共同封装在脂质体中，以同时执行多种功能，例如磁共振成像，磁性药物递送和热疗，[4]但相对于单组分脂质体，负载能力和稳定性通常会受到损害。已经有一些努力来开发固有的多功能纳米材料，如磁性纳米胶囊和发光多孔硅纳米颗粒来克服这些问题，[5，6]尽管这些更复杂的结构可能会失去 * msailor@ ucsd类型的多功能性。edu.
The ability of one structural type to perform multiple medical diagnostic or therapeutic functions is often cited as an advantageous characteristic of nanomaterials that cannot be achieved with organic small molecules.[1–3] Although there are now many examples of nanosystems that integrate multiple functions into a single structure, the designs can reduce the efficacy of the individual functions due to space and surface-chemistry limitations in the tiny platforms. For example, magnetic nanoparticles and drug molecules can be coencapsulated in liposomes to simultaneously perform multiple functions, such as magnetic resonance imaging, magnetic drug delivery and hyperthermia,[4] but the loading capacity and the stability are typically compromised relative to a single-component liposome. There has been some effort to develop intrinsically multifunctional nanomaterials such as magnetic nanocapsules and luminescent porous silicon nanoparticles to overcome such problems,[5, 6] although these more complicated structures may lose versatility in terms of the types of* msailor@ ucsd. edu.
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DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
DOI：
10.1016/s0360-3016(96)00389-6
发表时间：
1996-12-01
影响因子：
7
作者：
Gaber, MH;Wu, NZ;Papahadjopoulos, D
通讯作者：
Papahadjopoulos, D
影响因子：
29.4
作者：
von Maltzahn, Geoffrey;Centrone, Andrea;Park, Ji-Ho;Ramanathan, Renuka;Sailor, Michael J.;Hatton, T. Alan;Bhatia, Sangeeta N.
通讯作者：
Bhatia, Sangeeta N.
影响因子：
3.5
作者：
Tai, Lin-Ai;Tsai, Pi-Ju;Yang, Chung-Shi
通讯作者：
Yang, Chung-Shi
影响因子：
3.3
作者：
Jain, PK;Lee, KS;El-Sayed, MA
通讯作者：
El-Sayed, MA