Subcutaneous adipose cell size and distribution: relationship to insulin resistance and body fat.
Subcutaneous adipose cell size and distribution: relationship to insulin resistance and body fat.
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DOI：
10.1002/oby.20209
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发表时间：
2014-03
期刊：
影响因子：
6.9
通讯作者：
Cushman, S. W.
中科院分区：
文献类型：
--
作者：
McLaughlin, T.;Lamendola, C.;Coghlan, N.;Liu, T. C.;Lerner, K.;Sherman, A.;Cushman, S. W.
肥胖个体的代谢异质性可能归因于脂肪细胞大小的差异。我们试图通过量化超重/中度肥胖个体的脂肪细胞大小分布、体脂和胰岛素介导的葡萄糖摄取来阐明这一点。148例BMI 25-38 kg/m2的健康非糖尿病受试者接受皮下脂肪组织活检，并在改良胰岛素抑制试验期间用稳态血糖浓度（SSPG）定量胰岛素介导的葡萄糖摄取。用Beckman Coulter Multisizer获得细胞大小分布。主要终点包括小脂肪细胞%和大脂肪细胞直径。细胞大小和代谢参数进行了比较回归为整个组，根据IR和IS亚组，并通过身体脂肪五分位数。大脂肪细胞和小脂肪细胞几乎以相等的比例存在。小细胞百分比与SSPG相关（r=0.26，p=0.003）。与BMI匹配的IS个体相比，IR对应者表现出更少但更大的大脂肪细胞，以及更大比例的从小到大的脂肪细胞。大脂肪细胞的直径与体脂%（r=0.26，p=0.014）、女性（r=0.21，p=0.036）和SSPG（r=0.20，p=0.012）相关。在最高与最低的体脂百分比五分位数中，脂肪细胞大小仅增加7%，而脂肪细胞数量增加74%。需要招募脂肪细胞才能将体脂量扩大到BMI超过25 kg/m2。胰岛素抵抗与小脂肪细胞的积聚和大脂肪细胞的增大有关。这些数据支持脂肪生成受损可能是胰岛素抵抗的基础的观点。
Metabolic heterogeneity among obese individuals may be attributable to differences in adipose cell size. We sought to clarify this by quantifying adipose cell-size distribution, body fat, and insulin-mediated glucose uptake in overweight/moderately-obese individuals. 148 healthy nondiabetic subjects with BMI 25–38 kg/m2 underwent subcutaneous adipose tissue biopsies and quantification of insulin-mediated glucose uptake with steady-state plasma glucose concentrations (SSPG) during the modified insulin suppression test. Cell-size distributions were obtained with Beckman Coulter Multisizer. Primary endpoints included % small adipose cells and diameter of large adipose cells. Cell-size and metabolic parameters were compared by regression for the whole group; according to IR and IS subgroups; and by body fat quintile. Both large and small adipose cells were present in nearly equal proportions. Percent small cells was associated with SSPG (r=0.26, p=0.003). Compared to BMI-matched IS individuals, IR counterparts demonstrated fewer, but larger large adipose cells, and a greater proportion of small-to-large adipose cells. Diameter of the large adipose cells was associated with %body fat (r=0.26, p=0.014), female sex (r=0.21, p=0.036), and SSPG (r=0.20, p=0.012). In the highest vs lowest % body fat quintile, adipose cell size increased by only 7% whereas adipose cell number increased by 74%. Recruitment of adipose cells is required for expansion of body fat mass beyond BMI of 25 kg/m2. Insulin resistance is associated with accumulation of small adipose cells and enlargement of large adipose cells. These data support the notion that impaired adipogenesis may underlie insulin resistance.
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影响因子：
6.9
作者：
McLaughlin, Tracey M.;Liu, T.;Yee, Gail;Abbasi, F.;Lamendola, C.;Reaven, G. M.;Tsao, P.;Cushman, S. W.;Sherman, A.
通讯作者：
Sherman, A.
影响因子：
15.9
作者：
SALANS, LB;CUSHMAN, SW;WEISMANN, RE
通讯作者：
WEISMANN, RE
影响因子：
--
作者：
FAUST, IM;JOHNSON, PR;HIRSCH, J
通讯作者：
HIRSCH, J
影响因子：
3.6
作者：
DEURENBERG, P;WESTSTRATE, JA;SEIDELL, JC
通讯作者：
SEIDELL, JC
影响因子：
7.7
作者：
GREENFIELD, MS;DOBERNE, L;REAVEN, G
通讯作者：
REAVEN, G