Respiratory sinus arrhythmia and serotonin transporter promoter gene polymorphisms: taking a triallelic approach makes a difference.
Respiratory sinus arrhythmia and serotonin transporter promoter gene polymorphisms: taking a triallelic approach makes a difference.
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呼吸性窦性心律失常和血清素转运蛋白启动子基因多态性：采取三基因方法会产生影响。
作者：
R. Vulturar;A. Chiș;L. Ungureanu;A. Miu
最近在《精神生理学》中报道，5-羟色胺转运蛋白基因启动子区（5-HTTLPR）插入/缺失（ins/del）功能多态性的短等位基因携带者可能表现出静息呼吸性窦性心律失常（RSA）减少。然而，该区域存在另一个功能相关的单核苷酸多态性（rs 25531），也应该进行基因分型，以正确分类5-HTTLPR的低表达和高表达等位基因。本研究调查了静息RSA在一个种族同质样本（N = 143）的参与者基因型的ins/del和rs 25531多态性在5-HTTLPR。与仅基于插入/缺失等位基因的双等位基因基因型相比，三等位基因5-HTTLPR基因型（即，包括rs 25531）显示与静息RSA无关。因此，为了避免假阳性结果，对5-HTTLPR采取三等位基因方法是必要的。
It has been recently reported in Psychophysiology that carriers of the short allele of an insertion/deletion (ins/del) functional polymorphism in the promoter region (5-HTTLPR) of the serotonin transporter gene may display decreased resting respiratory sinus arrhythmia (RSA). However, this region hosts another functionally connected single-nucleotide polymorphism (rs25531), which should also be genotyped in order to correctly categorize the low- and high-expressing alleles of 5-HTTLPR. The present study investigated resting RSA in an ethnically homogenous sample (N = 143) of participants genotyped for both the ins/del and rs25531 polymorphisms in 5-HTTLPR. In contrast with the biallelic genotypes, based only on the ins/del alleles, the triallelic 5-HTTLPR genotypes (i.e., including rs25531) showed no association with resting RSA. Taking a triallelic approach to 5-HTTLPR is thus necessary in order to avoid false positive results.
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