Acute oral sodium propionate supplementation raises resting energy expenditure and lipid oxidation in fasted humans.
Acute oral sodium propionate supplementation raises resting energy expenditure and lipid oxidation in fasted humans.
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DOI：
10.1111/dom.13159
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Frost G
中科院分区：
文献类型：
--
作者：
Chambers ES;Byrne CS;Aspey K;Chen Y;Khan S;Morrison DJ;Frost G
短链脂肪酸（SCFAs）是由肠道菌群发酵膳食纤维产生的，被认为可以调节能量代谢。先前使用啮齿动物模型的研究表明，口服丙酸SCFA通过促进脂质氧化来提高静息能量消耗（REE）。本研究的目的是探讨口服丙酸钠对人体稀土元素和底物代谢的影响。18名健康志愿者（9名女性和9名男性，年龄25±1岁，体重指数24.1±1.2 kg/m2）在禁食一夜后完成了2次研究访问。在180分钟的研究期间，按随机顺序提供总共含有6845 mg丙酸钠或4164 mg氯化钠的片剂。用间接量热法测定稀土元素和底物氧化。口服丙酸钠增加REE(0.045±0.020 kcal/min; P = 0.036)；这伴随着全身脂质氧化率升高(0.012±0.006 g/min; P =。048)并且独立于葡萄糖和胰岛素浓度的变化。未来的研究需要确定口服丙酸钠对REE的急性影响是否转化为对人类长期能量平衡的积极改善。
Short‐chain fatty acids (SCFAs), produced from fermentation of dietary fibre by the gut microbiota, have been suggested to modulate energy metabolism. Previous work using rodent models has demonstrated that oral supplementation of the SCFA propionate raises resting energy expenditure (REE) by promoting lipid oxidation. The objective of the present study was to investigate the effects of oral sodium propionate on REE and substrate metabolism in humans. Eighteen healthy volunteers (9 women and 9 men; age 25 ± 1 years; body mass index 24.1 ± 1.2 kg/m2) completed 2 study visits following an overnight fast. Tablets containing a total of 6845 mg sodium propionate or 4164 mg sodium chloride were provided over the 180‐minute study period in random order. REE and substrate oxidation were assessed by indirect calorimetry. Oral sodium propionate administration increased REE (0.045 ± 0.020 kcal/min; P = .036); this was accompanied by elevated rates of whole‐body lipid oxidation (0.012 ± 0.006 g/min; P = .048) and was independent of changes in glucose and insulin concentrations. Future studies are warranted to determine whether the acute effects of oral sodium propionate on REE translate into positive improvements in long‐term energy balance in humans.
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肠道菌群通过短链脂肪酸受体GPR43抑制胰岛素介导的脂肪积累。
影响因子：
16.6
作者：
通讯作者：
--
肠道微生物群形成短链脂肪酸及其对人代谢的影响。
影响因子：
12.2
作者：
Morrison DJ;Preston T
通讯作者：
Preston T
DOI：
10.1126/science.1241214
发表时间：
2013-09-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ridaura VK;Faith JJ;Rey FE;Cheng J;Duncan AE;Kau AL;Griffin NW;Lombard V;Henrissat B;Bain JR;Muehlbauer MJ;Ilkayeva O;Semenkovich CF;Funai K;Hayashi DK;Lyle BJ;Martini MC;Ursell LK;Clemente JC;Van Treuren W;Walters WA;Knight R;Newgard CB;Heath AC;Gordon JI
通讯作者：
Gordon JI
影响因子：
7.7
作者：
den Besten, Gijs;Bleeker, Aycha;Bakker, Barbara M.
通讯作者：
Bakker, Barbara M.
影响因子：
2.5
作者：
Kummitha CM;Kalhan SC;Saidel GM;Lai N
通讯作者：
Lai N