Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging.
Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging.
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DOI：
10.1002/mrm.21712
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发表时间：
2008-10
影响因子：
3.3
通讯作者：
van Zijl, Peter C. M.
中科院分区：
文献类型：
--
作者：
Zhou, Jinyuan;Blakeley, Jaishri O.;Hua, Jun;Kim, Mina;Laterra, John;Pomper, Martin G.;van Zijl, Peter C. M.
酰胺质子转移（APT）成像是一种化学交换依赖饱和转移（CEST）磁共振成像（MRI），其中检测组织中内源性移动的蛋白质和肽的酰胺质子。最初的研究表明，有希望区分患者的肿瘤和周围的大脑，但这一数据受到磁场不均匀性和低信噪比（SNR）的阻碍。这里提出了一种实用的六偏移APT数据采集方案，该方案与单独采集的CEST谱一起，可以在临床相关的时间帧内提供具有足够SNR的B0不均匀性校正的人脑APT图像。来自9名脑肿瘤患者的3T数据显示，在高级别肿瘤患者中，肿瘤核心（由钆增强分配）的APT强度显著高于对侧正常出现的白色物质（CNAWM）。相反，在低级别肿瘤患者中，肿瘤中的APT强度与CNAWM无法区分。在高级别肿瘤中，APT增加的区域延伸到核心区域以外的外围区域，表明该技术具有更准确地描绘脑癌异质区域的潜力。
Amide Proton Transfer (APT) imaging is a type of chemical exchange dependent saturation transfer (CEST) magnetic resonance imaging (MRI), in which amide protons of endogenous mobile proteins and peptides in tissue are detected. Initial studies have shown promise to distinguish tumor from surrounding brain in patients, but this data was hampered by magnetic field inhomogeneity and by low signal to noise ratio (SNR). Here a practical six-offset APT data acquisition scheme is presented that, together with a separately acquired CEST spectrum, can provide B0-inhomogeneity corrected human brain APT images of sufficient SNR within a clinically relevant time frame. Data from nine brain tumor patients at 3T shows that APT intensities were significantly higher in the tumor core, as assigned by gadolinium-enhancement, than in contralateral normal appearing white matter (CNAWM) in patients with high-grade tumors. Conversely, APT intensities in tumor were indistinguishable from CNAWM in patients with low-grade tumors. In high-grade tumors, regions of increased APT extended outside of the core into peripheral zones, indicating the potential of this technique for more accurate delineation of the heterogeneous areas of brain cancers.
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