Longitudinal lipidomic profiles during pregnancy and associations with neonatal anthropometry: findings from a multiracial cohort.
Longitudinal lipidomic profiles during pregnancy and associations with neonatal anthropometry: findings from a multiracial cohort.
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DOI：
10.1016/j.ebiom.2023.104881
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发表时间：
2023-12
期刊：
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
母体脂质组学分析提供了表征妊娠期间脂质代谢物的希望，但纵向数据有限。本研究旨在利用多种族队列的数据，检查妊娠期间的纵向脂质组学特征与多个新生儿人体测量的关联。我们测量了来自NICHD胎儿生长研究-单胎的321名孕妇的非靶向血浆脂质谱，这些孕妇分别在妊娠周（GW） 10-14、15-26、23-31和33-39进行了四次纵向研究访问。我们在每次研究访问中评估与新生儿人体测量相关的个体脂质组代谢物。我们还通过使用加权相关网络分析构建脂质网络和使用共识网络分析的共同网络来纵向评估关联，使用线性混合效应模型对四次就诊进行了调整，并调整了错误发现率。多种甘油三酯（TG）与出生体重（BW）、BW Z-score、体长和头围呈正相关，而某些胆固醇酯（CE）、磷脂酰胆碱（PC）、鞘磷脂（SM）、磷脂酰乙醇胺（PE）和溶血磷脂酰胆碱（LPC）家族与不同出生年龄时的体重、体长、腹部和头围呈负相关。TG、PC和葡萄糖酰脂（GlcCer）的纵向轨迹与体重相关，CE（18:2）与体重z-score、长度和皮肤褶皱总数（SS）相关，而部分PC和PE与腹围和头围显著相关。GW 10-14和15-26的TG模块主要与体重相关。在GW 33-39时，LPC（20:3）和PC、TG和CE的两个网络与腹围呈负相关。随着TG、CE、PC和LPC的变化，两个共识模块内的不同轨迹显示出体重和长度的显著差异。结果表明，妊娠早期和中期TGs的纵向变化以及妊娠晚期PC、LPC和CE的变化与新生儿人体测量有显著相关性。校内的资金。
Maternal lipidomic profiling offers promise for characterizing lipid metabolites during pregnancy, but longitudinal data are limited. This study aimed to examine associations of longitudinal lipidomic profiles during pregnancy with multiple neonatal anthropometry using data from a multiracial cohort. We measured untargeted plasma lipidome profiles among 321 pregnant women from the NICHD Fetal Growth Study-Singletons using plasma samples collected longitudinally during four study visits at gestational weeks (GW) 10–14, 15–26, 23–31, and 33–39, respectively. We evaluated individual lipidomic metabolites at each study visit in association with neonatal anthropometry. We also evaluated the associations longitudinally by constructing lipid networks using weighted correlation network analysis and common networks using consensus network analysis across four visits using linear mixed-effects models with the adjustment of false discover rate. Multiple triglycerides (TG) were positively associated with birth weight (BW), BW Z-score, length and head circumference, while some cholesteryl ester (CE), phosphatidylcholine (PC), sphingomyelines (SM), phosphatidylethanolamines (PE), and lysophosphatidylcholines (LPC 20:3) families were inversely associated with BW, length, abdominal and head circumference at different GWs. Longitudinal trajectories of TG, PC, and glucosylcermides (GlcCer) were associated with BW, and CE (18:2) with BW z-score, length, and sum of skinfolds (SS), while some PC and PE were significantly associated with abdominal and head circumference. Modules of TG at GW 10–14 and 15–26 mainly were associated with BW. At GW 33–39, two networks of LPC (20:3) and of PC, TG, and CE, showed inverse associations with abdominal circumference. Distinct trajectories within two consensus modules with changes in TG, CE, PC, and LPC showed significant differences in BW and length. The results demonstrated that longitudinal changes of TGs during early- and mid-pregnancy and changes of PC, LPC, and CE during late-pregnancy were significantly associated with neonatal anthropometry. intramural funding.
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