Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors.
Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors.
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DOI：
10.1038/s41398-023-02664-3
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发表时间：
2023-11-22
影响因子：
6.8
通讯作者：
Xu, Shifen
中科院分区：
文献类型：
--
作者：
Li, Wei;Shen, Zuqi;Yin, Xuan;Chang, Weiqi;Chen, Xiaorong;Yu, Jin;Xu, Shifen
抑郁症的病理与多种神经递质失衡有关。中缝背核（DRN）是产生5-HT的主要脑区，在抑郁症的病理生理过程中起着至关重要的作用。它包含几种神经元类型，其中GABA能神经元被与负面经历相关的刺激激活，5-HT神经元被奖励信号激活。然而，对其潜在的分子机制知之甚少。在这里，我们发现，p11，与抑郁症相关的多功能蛋白质，在5-HTDRN神经元中被慢性社会失败压力下调。在DRN中敲低p11可诱导抑郁样行为，而在5-HTDRN神经元中过表达p11可减轻慢性社会失败应激引起的抑郁样行为。此外，p11调节膜运输的谷氨酸受体在5-HTDRN神经元，这表明一个可能的分子机制的p11参与抑郁症的病理过程。这可能有助于理解抑郁症的分子和细胞基础。
The pathology of depression is related to the imbalance of various neurotransmitters. The dorsal raphe nucleus (DRN), the main brain region producing 5-HT, is crucially involved in the pathophysiology of depression. It contains several neuron types, in which GABAergic neurons are activated by stimuli associated with negative experiences and 5-HT neurons are activated by reward signals. However, little is known about its underlying molecular mechanisms. Here, we found that p11, a multifunctional protein associated with depression, was down-regulated by chronic social defeat stress in 5-HTDRN neurons. Knockdown of p11 in DRN induced depression-like behaviors, while its overexpression in 5-HTDRN neurons alleviated depression-like behavior caused by chronic social defeat stress. Further, p11 regulates membrane trafficking of glutamate receptors in 5-HTDRN neurons, suggesting a possible molecular mechanism underlying the participation of p11 in the pathological process of depression. This may facilitate the understanding of the molecular and cellular basis of depression.
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影响因子：
9
作者：
Holloway, Ryan W.;Thomas, Margaret L.;Waisman, David M.
通讯作者：
Waisman, David M.
DOI：
10.1111/j.1460-9568.2011.07936.x
发表时间：
2012-01
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Bang SJ;Jensen P;Dymecki SM;Commons KG
通讯作者：
Commons KG
影响因子：
4.1
作者：
Hernandez-Vazquez, Fabiola;Garduno, Julieta;Hernandez-Lopez, Salvador
通讯作者：
Hernandez-Lopez, Salvador
反应于物质P的背raphe核中局部副谷氨酸神经元包含囊泡谷氨酸转运蛋白3（VGLUT3）。
影响因子：
2.8
作者：
Commons KG
通讯作者：
Commons KG
影响因子：
17.1
作者：
Alexander B;Warner-Schmidt J;Eriksson T;Tamminga C;Arango-Lievano M;Ghose S;Vernov M;Stavarache M;Musatov S;Flajolet M;Svenningsson P;Greengard P;Kaplitt MG
通讯作者：
Kaplitt MG