Incident dementia and faster rates of cognitive decline are associated with worse multisensory function summary scores.
Incident dementia and faster rates of cognitive decline are associated with worse multisensory function summary scores.
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DOI：
10.1002/alz.12134
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Yaffe K
中科院分区：
文献类型：
--
作者：
Brenowitz WD;Kaup AR;Yaffe K
我们创建了一种多感觉损伤的综合测量方法，并评估了其与痴呆的关系。我们研究了1794名70至79岁的成年人，他们在入组时没有痴呆症，并在健康、衰老和身体成分研究中随访了长达10年。多感官功能评分（0 ~ 12分）是基于客观测量的视觉、听觉、嗅觉和触觉的样本四分位数的总和。在根据人口统计和健康状况进行调整的回归模型中，评估了与得分相关的痴呆发生率和认知能力下降（通过两次认知测试测量）的风险。与“差”和“好”多感官评分分位数相比，痴呆风险高2.05倍（95%置信区间[CI] 1.50-2.81），与“中”和“好”分位数相比，痴呆风险高1.45倍（95% CI 1.09-1.91）。多感觉功能评分越差，认知能力下降速度越快（P < 0.05）。多感觉功能的恶化，即使是轻微的程度，也与认知老化的加速有关。
We created a summary measure of multiple sensory (multisensory) impairment and evaluated its association with dementia. We studied 1794 adults aged 70 to 79 who were dementia-free at enrollment and followed for up to 10 years in the Health, Aging, and Body Composition Study. The multisensory function score (0 to 12 points) was based on sample quartiles of objectively measured vision, hearing, smell, and touch summed overall. Risk of incident dementia and cognitive decline (measured by two cognitive tests) associated with the score were assessed in regression models adjusting for demographics and health conditions. Dementia risk was 2.05 times higher (95% confidence interval [CI] 1.50-2.81) comparing “poor” to ”good” multisensory score tertiles and 1.45 times higher comparing the “middle” to “good” tertiles (95% CI 1.09-1.91). Each point worse multisensory function score was associated with faster rates of cognitive decline (P < .05). Worsening multisensory function, even at mild levels, was associated with accelerated cognitive aging.
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影响因子：
6.3
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
5.4
作者：
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通讯作者：
Robins, JM
DOI：
10.1111/j.1532-5415.2004.52554.x
发表时间：
2004-12-01
影响因子：
6.3
作者：
Lin, MY;Gutierrez, PR;Mangione, CM
通讯作者：
Mangione, CM