Age-Related Sensory Impairments and Risk of Cognitive Impairment.
Age-Related Sensory Impairments and Risk of Cognitive Impairment.
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DOI：
10.1111/jgs.14308
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发表时间：
2016-10
影响因子：
6.3
通讯作者：
Tweed TS
中科院分区：
文献类型：
--
作者：
Fischer ME;Cruickshanks KJ;Schubert CR;Pinto AA;Carlsson CM;Klein BE;Klein R;Tweed TS
评估感觉障碍与10年认知障碍风险的关系。以前的工作主要集中在一个单一的感觉系统和认知之间的关系。听力损失流行病学研究（EHLS）是一项在威斯康星州比弗坝社区进行的纵向、基于人群的老龄化研究。基线检查于1993年进行，随访检查每5年进行一次。在EHLS-2（1998-2000）中没有认知障碍的一般社区EHLS成员。共有1，884名参与者（平均年龄= 66.7岁）具有完整的EHLS-2感觉数据和随访信息。认知障碍是简易精神状态检查评分< 24或有痴呆或阿尔茨海默病史。听力障碍是每只耳朵的纯音平均听力阈值（0.5、1、2和4 kHz）> 25分贝听力水平。视力受损是指视力较好的眼睛的Pelli-Robson对比敏感度< 1.55 log单位，嗅觉受损是指圣地亚哥气味识别测试评分< 6。听力、视觉和嗅觉障碍与认知障碍风险独立相关[听力：风险比（HR）= 1.90，95%置信区间（C.I.）= 1.11，3.26;视力：HR = 2.05，95% C.I. = 1.24，3.38;嗅觉：HR = 3.92，95% C.I. = 2.45，6.26]。然而，85%的听力障碍患者、81%的视力障碍患者和76%的嗅觉障碍患者在随访期间没有出现认知障碍。感觉障碍和认知障碍之间的关系并不是一个感觉系统所独有的，这表明感觉神经健康可能是大脑老化的标志。联合感觉神经认知测量的发展可能有助于揭示健康大脑衰老的机制。
To evaluate the associations of sensory impairments with the 10-year risk of cognitive impairment. Previous work has primarily focused on the relationship between a single sensory system and cognition. The Epidemiology of Hearing Loss Study (EHLS) is a longitudinal, population-based study of aging in the Beaver Dam, WI community. Baseline examinations were conducted in 1993 and follow-up exams have been conducted every 5 years. General community EHLS members without cognitive impairment at EHLS-2 (1998–2000). There were 1,884 participants (mean age = 66.7 years) with complete EHLS-2 sensory data and follow-up information. Cognitive impairment was a Mini-Mental State Examination score of < 24 or history of dementia or Alzheimer’s disease. Hearing impairment was a pure-tone average of hearing thresholds (0.5, 1, 2 and 4 kHz) of > 25 decibel Hearing Level in either ear. Visual impairment was Pelli-Robson contrast sensitivity of < 1.55 log units in the better eye and olfactory impairment was a San Diego Odor Identification Test score of < 6. Hearing, visual, and olfactory impairment were independently associated with cognitive impairment risk [Hearing: Hazard Ratio (HR) = 1.90, 95% Confidence Interval (C.I.) = 1.11, 3.26; Vision: HR = 2.05, 95% C.I. = 1.24, 3.38; Olfaction: HR = 3.92, 95% C.I. = 2.45, 6.26]. However, 85% with hearing impairment, 81% with visual impairment, and 76% with olfactory impairment did not develop cognitive impairment during follow-up. The relationship between sensory impairment and cognitive impairment was not unique to one sensory system suggesting sensorineural health may be a marker of brain aging. The development of a combined sensorineurocognitive measure may be useful in uncovering mechanisms of healthy brain aging.
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影响因子：
39.3
作者：
Kaffashian S;Dugravot A;Nabi H;Batty GD;Brunner E;Kivimäki M;Singh-Manoux A
通讯作者：
Singh-Manoux A
影响因子：
5.7
作者：
Dalton, DS;Cruickshanks, KJ;Nondahl, DM
通讯作者：
Nondahl, DM
影响因子：
6.3
作者：
Cruickshanks KJ;Nondahl DM;Dalton DS;Fischer ME;Klein BE;Klein R;Nieto FJ;Schubert CR;Tweed TS
通讯作者：
Tweed TS
影响因子：
2.8
作者：
Karpa, Michael J.;Gopinath, Bamini;Mitchell, Paul
通讯作者：
Mitchell, Paul
影响因子：
3.7
作者：
KAPLAN, EL;MEIER, P
通讯作者：
MEIER, P