Increased cancer risks for relatives of very early-onset breast cancer cases with and without BRCA1 and BRCA2 mutations.
Increased cancer risks for relatives of very early-onset breast cancer cases with and without BRCA1 and BRCA2 mutations.
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DOI：
10.1038/sj.bjc.6605876
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发表时间：
2010-09-28
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
关于极早发性乳腺癌妇女的亲属患癌风险知之甚少。我们研究了504名在35岁之前诊断为乳腺癌的白人女性的2208名父母和兄弟姐妹（103名来自美国，124名来自加拿大，277名来自澳大利亚），其中41名已知携带突变（24名BRCA 1，16名BRCA 2和1名两种基因）。通过比较受影响亲属的数量（总体验证为50%）与基于国家、性别、年龄和出生年份特定发病率的预期数量，估计癌症特异性标准化发病率（SIR）。BRCA 1和BRCA 2携带者亲属的女性乳腺癌SIR分别为13.13（95% CI 6.57-26.26）和12.52（5.21-30.07）。BRCA 1的卵巢癌SIR为12.38（3.1-49.51），BRCA 2的前列腺癌SIR为18.55（4.64-74.17）。女性乳腺癌、前列腺癌、肺癌、脑癌和泌尿系癌的SIR分别为4.03（2.91-5.93）、5.25（2.50-11.01）、7.73（4.74-12.62）、5.19（2.33-11.54）和4.35（1.81-10.46）。对于非携带者，SIRs仍然升高，并且当基于经验证的癌症时，对于乳腺癌和前列腺癌具有统计学显著性。极早发性乳腺癌女性的一级亲属患BRCA 1和BRCA 2突变无法解释的癌症的风险增加。
Little is known regarding cancer risks for relatives of women with very early-onset breast cancer. We studied 2208 parents and siblings of 504 unselected population-based Caucasian women with breast cancer diagnosed before age 35 years (103 from USA, 124 from Canada and 277 from Australia), 41 known to carry a mutation (24 in BRCA1, 16 in BRCA2 and one in both genes). Cancer-specific standardised incidence ratios (SIRs) were estimated by comparing the number of affected relatives (50% verified overall) with that expected based on incidences specific for country, sex, age and year of birth. For relatives of carriers, the female breast cancer SIRs were 13.13 (95% CI 6.57–26.26) and 12.52 (5.21–30.07) for BRCA1 and BRCA2, respectively. The ovarian cancer SIR was 12.38 (3.1–49.51) for BRCA1 and the prostate cancer SIR was 18.55 (4.64–74.17) for BRCA2. For relatives of non-carriers, the SIRs for female breast, prostate, lung, brain and urinary cancers were 4.03 (2.91–5.93), 5.25 (2.50–11.01), 7.73 (4.74–12.62), 5.19 (2.33–11.54) and 4.35 (1.81–10.46), respectively. For non-carriers, the SIRs remained elevated and were statistically significant for breast and prostate cancer when based on verified cancers. First-degree relatives of women with very early-onset breast cancer are at increased risk of cancers not explained by BRCA1 and BRCA2 mutations.
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影响因子：
64.8
作者：
WOOSTER, R;BIGNELL, G;STRATTON, MR
通讯作者：
STRATTON, MR
影响因子：
8.4
作者：
Hemminki, K;Granström, C
通讯作者：
Granström, C
影响因子：
11.5
作者：
Willems, Amber J.;Dawson, Sarah-Jane;Thorne, Heather J.
通讯作者：
Thorne, Heather J.
影响因子：
5
作者：
Anderson, H;Bladström, A;Möller, TR
通讯作者：
Möller, TR
影响因子：
5.5
作者：
Ziogas, A;Anton-Culver, H
通讯作者：
Anton-Culver, H