Multifunctional PLGA microfibrous rings enable MR imaging-guided tumor chemotherapy and metastasis inhibition through prevention of circulating tumor cell shedding
Multifunctional PLGA microfibrous rings enable MR imaging-guided tumor chemotherapy and metastasis inhibition through prevention of circulating tumor cell shedding
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多功能 PLGA 微纤维环可通过防止循环肿瘤细胞脱落来实现 MR 成像引导的肿瘤化疗和转移抑制
DOI：
10.1016/j.nantod.2021.101123
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发表时间：
2021-06
期刊：
影响因子：
17.4
通讯作者：
Shi Xiangyang
中科院分区：
文献类型：
--
作者：
Xiao Yunchao;Fan Yu;Tu Wenzhi;Ning Yuesheng;Zhu Meifang;Liu Yong;Shi Xiangyang
同时抑制肿瘤和肿瘤转移可以被认为是癌症治疗的理想和最终目标。我们报告了一种基于DNA适体功能化微纤维环的独特平台，用于同时抑制原发性肿瘤和肿瘤转移。制备负载多柔比星的电纺聚（乳酸-共-乙醇酸）纤维垫，并在盐的存在下均质化以形成微纤维环，所述微纤维环用钆螯合物和DNA适体介导的缀合物官能化。多功能纤维环的平均直径为11.1 µm，具有良好的生物相容性、pH依赖性长期药物释放曲线和高r1弛豫率。由于环结构和DNA适体功能化，多功能纤维环能够靶向并锚肿瘤细胞相对长的保留时间，如通过磁共振成像所证实的，从而减少肿瘤细胞脱落到血液中以形成循环肿瘤细胞并抑制肿瘤转移和侵袭。
Simultaneous inhibition of tumors and tumor metastasis can be considered as an ideal and ultimate goal for cancer therapy. We report a unique platform based on DNA aptamer-functionalized microfibrous rings for simultaneous inhibition of primary tumors and tumor metastasis. Doxorubicin-loaded electrospun poly(lactic-co-glycolic acid) fibrous mat was prepared and homogenized in the presence of salt to form microfibrous rings that were functionalized with gadolinium chelates and DNA aptamerviapolyethyleneimine-mediated conjugation. The multifunctional fibrous rings have an average diameter of 11.1 µm, and exhibit good biocompatibility, pH-dependent long-term drug release profile, and a high r1relaxivity. Due to the ring structure and the DNA aptamer functionalization, the multifunctional fibrous rings are able to target and anchor tumor cells for a relatively long retention time as verified by magnetic resonance imaging, consequently decreasing the tumor cell shedding into the blood to form circulating tumor cells and inhibiting tumor metastasis and invasion.
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影响因子：
3
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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影响因子：
9.5
作者：
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5.8
作者：
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