Ultrasonographic features of ovarian morphology capture nutritional and metabolic influences on the reproductive axis: implications for biomarker development in ovulatory disorders.

Ultrasonographic features of ovarian morphology capture nutritional and metabolic influences on the reproductive axis: implications for biomarker development in ovulatory disorders.
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DOI:
10.1016/j.copbio.2020.10.008
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发表时间:
2021-08
影响因子:
7.7
通讯作者:
Lujan ME
Lujan ME
中科院分区:
工程技术1区
文献类型:
--
作者:
Vanden Brink H;Pea J;Lujan ME

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Ultrasonographic imaging of ovarian morphology is used widely to inform reproductive health status in women. Metabolic disturbances induced by a negative energy balance (e.g., undernutrition) or positive energy balance (e.g., overnutrition, obesity) are known to drive or exacerbate reproductive dysfunction. Whether the utility of ultrasonographic metrics of ovarian morphology could be extended as biomarkers that detect and monitor the integration of metabolic and reproductive dysfunction is an emerging research area, and recent evidence is discussed. We note that unique variations in ovarian morphology emerge across the adiposity spectrum and highlight the potential for reproductive and metabolic “tipping points” upon which such morphological variations may be detected on ultrasonography.
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