Endophytic fungi: a reservoir of antibacterials.
Endophytic fungi: a reservoir of antibacterials.
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DOI：
10.3389/fmicb.2014.00715
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发表时间：
2014
影响因子：
5.2
通讯作者：
Bhave SV
中科院分区：
文献类型：
--
作者：
Deshmukh SK;Verekar SA;Bhave SV
耐多药细菌正变得越来越成问题，特别是在世界欠发达国家。数量呈几何级数增长的最重要的微生物是耐甲氧西林的金黄色葡萄球菌、耐万古霉素的屎肠球菌、耐青霉素的肺炎链球菌和多重耐药的结核杆菌，仅举几例。新的药物支架对于解决这一日益严重的问题至关重要。这些脚手架可以来自大自然本身。内生真菌是治疗活性化合物的重要储存库。这篇综述试图提供一些与这个问题相关的数据。需要新的、非常具体和有效的抗生素，但价格也是负担得起的！对于世界各地的研究人员来说，这是一项艰巨的任务！在亚洲次大陆，几个世纪以来一直沿用的土著疗法，如阿育吠陀，在家族世代中被当作“传承资料”而有效。可能需要第二次、第三次以及更深入的调查？
Multidrug drug resistant bacteria are becoming increasingly problematic particularly in the under developed countries of the world. The most important microorganisms that have seen a geometric rise in numbers are Methicillin resistant Staphylococcus aureus, Vancomycin resistant Enterococcus faecium, Penicillin resistant Streptococcus pneumonia and multiple drug resistant tubercule bacteria to name a just few. New drug scaffolds are essential to tackle this every increasing problem. These scaffolds can be sourced from nature itself. Endophytic fungi are an important reservoir of therapeutically active compounds. This review attempts to present some data relevant to the problem. New, very specific and effective antibiotics are needed but also at an affordable price! A Herculean task for researchers all over the world! In the Asian subcontinent indigenous therapeutics that has been practiced over the centuries such as Ayurveda have been effective as “handed down data” in family generations. May need a second, third and more “in-depth investigations?”
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影响因子：
15
作者：
Brady, SF;Bondi, SM;Clardy, J
通讯作者：
Clardy, J
影响因子：
5.1
作者：
Chomeheon, P;Wiyakrutta, S;Kittakoop, P
通讯作者：
Kittakoop, P
影响因子：
2.8
作者：
Dai, JQ;Krohn, K;Rheinheimer, J
通讯作者：
Rheinheimer, J
影响因子：
3
作者：
Devi, Prabha;Rodrigues, Cheryl;D'Souza, L.
通讯作者：
D'Souza, L.
影响因子：
1.7
作者：
Cheng, Ming-Jen;Wu, Ming-Der;Chen, Jih-Jung
通讯作者：
Chen, Jih-Jung