Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis.
Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis.
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DOI：
10.3969/j.issn.1673-5374.2013.19.003
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发表时间：
2013-07-05
影响因子：
6.1
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Chen Z;Yang S;He Y;Song C;Liu Y
以往的研究表明，从蚕茧中提取的丝胶蛋白可以显著降低血糖水平，保护神经系统免受糖尿病的侵害。本实验采用连续3 d腹腔注射链脲佐菌素25 mg/kg建立2型糖尿病大鼠模型，随后给予丝胶治疗35 d。治疗后，糖尿病大鼠血糖水平显著降低，血清中生长激素水平及海马中生长激素表达显著降低，血清中胰岛素样生长因子-1水平及海马中胰岛素样生长因子-1及生长激素受体表达显著升高。实验结果表明丝胶可改善生长激素/胰岛素样生长因子1轴紊乱，减轻糖尿病大鼠海马损伤。
Previous studies have shown that sericin extracted from silk cocoon significantly reduces blood glucose levels and protects the nervous system against diabetes mellitus. In this study, a rat type 2 diabetes mellitus model was established by intraperitoneal injection of 25 mg/kg streptozotocin for 3 successive days, following which the rats were treated with sericin for 35 days. After treatment, the blood glucose levels of the diabetic rats decreased significantly, the growth hormone level in serum and its expression in the hippocampus decreased significantly, while the insulin-like growth factor-1 level in serum and insulin-like growth factor-1 and growth hormone receptor expression in the hippocampus increased significantly. The experimental findings indicate that sericin improves disorders of the growth hormone/insulin-like growth factor 1 axis to alleviate hippocampal damage in diabetic rats.
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影响因子：
64.5
作者：
Cao P;Maximov A;Südhof TC
通讯作者：
Südhof TC
二甲双胍，磺酰脲或其他抗糖尿病药物以及乳酸性酸中毒或低血糖的风险：嵌套的病例对照分析。
影响因子：
16.2
作者：
Bodmer, Michael;Meier, Christian;Kraehenbuehl, Stephan;Jick, Susan S.;Meier, Christoph R.
通讯作者：
Meier, Christoph R.
影响因子：
6.1
作者：
Chen, Zhihong;He, Yaqiang;Xue, Jingfeng
通讯作者：
Xue, Jingfeng
影响因子：
6.1
作者：
Chen, Zhihong;He, Yaqiang;Xue, Jingfeng
通讯作者：
Xue, Jingfeng
影响因子：
0.5
作者：
Consoli, Agostino;Di Biagio, Rosamaria
通讯作者：
Di Biagio, Rosamaria