Catecholaminergic contributions to vocal communication signals
Catecholaminergic contributions to vocal communication signals
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儿茶酚胺能对声音交流信号的贡献
DOI：
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发表时间：
2015
影响因子：
3.4
通讯作者：
J. Sakata
中科院分区：
文献类型：
--
作者：
Laura E Matheson;J. Sakata
社会环境影响各种物种的行为表现。例如，社会背景会严重影响语音通信信号（如语音和鸟鸣）的声学和时间结构。尽管这种社会影响的普遍性和重要性，很少有人知道的神经机制的社会调制的沟通。儿茶酚胺参与社会行为和运动控制的调节，但儿茶酚胺影响声音通信信号的程度在很大程度上仍然未知。使用鸣禽孟加拉雀，我们研究了产生歌曲的社会背景影响中脑中儿茶酚胺合成神经元中立即早期基因表达（EGR-1）的程度。此外，我们评估了安非他明（增加大脑中儿茶酚胺浓度）的给药程度，以模仿社会背景对声音信号的影响。我们发现，在暴露于雌性并产生求偶歌曲的鸟类中，腹侧被盖区和黑质（但不是中央灰质，蓝斑或蓝斑下）中的儿茶酚胺能神经元表达EGR-1的数量明显多于单独产生非求偶歌曲的鸟类。此外，我们发现，安非他明管理模仿社会背景的影响，并导致非求偶歌曲的许多方面类似于求偶歌曲。安非他明增加了音节结构和序列的刻板性，增加了发音成分的重复和序列完成的程度。总之，这些数据突出了儿茶酚胺在包括鸣禽和人类在内的物种之间的声音交流中的保守作用。
Social context affects behavioral displays across a variety of species. For example, social context acutely influences the acoustic and temporal structure of vocal communication signals such as speech and birdsong. Despite the prevalence and importance of such social influences, little is known about the neural mechanisms underlying the social modulation of communication. Catecholamines are implicated in the regulation of social behavior and motor control, but the degree to which catecholamines influence vocal communication signals remains largely unknown. Using a songbird, the Bengalese finch, we examined the extent to which the social context in which song is produced affected immediate early gene expression (EGR‐1) in catecholamine‐synthesising neurons in the midbrain. Further, we assessed the degree to which administration of amphetamine, which increases catecholamine concentrations in the brain, mimicked the effect of social context on vocal signals. We found that significantly more catecholaminergic neurons in the ventral tegmental area and substantia nigra (but not the central grey, locus coeruleus or subcoeruleus) expressed EGR‐1 in birds that were exposed to females and produced courtship song than in birds that produced non‐courtship song in isolation. Furthermore, we found that amphetamine administration mimicked the effects of social context and caused many aspects of non‐courtship song to resemble courtship song. Specifically, amphetamine increased the stereotypy of syllable structure and sequencing, the repetition of vocal elements and the degree of sequence completions. Taken together, these data highlight the conserved role of catecholamines in vocal communication across species, including songbirds and humans.
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