An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.
An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.
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DOI：
10.1002/hbm.24972
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发表时间：
2022-01
影响因子：
4.8
通讯作者：
ENIGMA-OCD working group
中科院分区：
文献类型：
--
作者：
van den Heuvel OA;Boedhoe PSW;Bertolin S;Bruin WB;Francks C;Ivanov I;Jahanshad N;Kong XZ;Kwon JS;O'Neill J;Paus T;Patel Y;Piras F;Schmaal L;Soriano-Mas C;Spalletta G;van Wingen GA;Yun JY;Vriend C;Simpson HB;van Rooij D;Hoexter MQ;Hoogman M;Buitelaar JK;Arnold P;Beucke JC;Benedetti F;Bollettini I;Bose A;Brennan BP;De Nadai AS;Fitzgerald K;Gruner P;Grünblatt E;Hirano Y;Huyser C;James A;Koch K;Kvale G;Lazaro L;Lochner C;Marsh R;Mataix-Cols D;Morgado P;Nakamae T;Nakao T;Narayanaswamy JC;Nurmi E;Pittenger C;Reddy YCJ;Sato JR;Soreni N;Stewart SE;Taylor SF;Tolin D;Thomopoulos SI;Veltman DJ;Venkatasubramanian G;Walitza S;Wang Z;Thompson PM;Stein DJ;ENIGMA-OCD working group
神经影像学在促进我们对强迫症（OCD）神经生物学的理解方面发挥了重要作用。与此同时，强迫症的神经影像学研究有明显的局限性，包括依赖于相对较小的样本。ENIGMA联盟支持通过合并来自不同研究中心的样本来提高统计能力的国际合作努力;这为进行多中心分析提供了特定的技术专业知识，并可以访问神经影像科学家的协作社区。在本文中，我们概述了ENIGMA强迫症工作组的背景、发展和初步发现，该工作组目前由来自5大洲15个国家34个研究所的47个样本组成，总样本量为2，323名强迫症患者和2，325名健康对照。最初的工作集中在研究皮质厚度和皮质下体积，结构连接性和强迫症儿童，青少年和成人的大脑侧化，还包括研究不同神经发育障碍的共性和区别。目前正在使用机器学习技术开展更多工作。迄今为止的研究结果有助于开发强迫症的神经生物学模型，提供了全球科学合作的重要模式，并具有许多临床意义。重要的是，我们的工作为关于强迫症中发现的结构和功能改变是否反映神经发育变化、疾病过程的影响或药物影响的问题提供了新的线索。最后，我们总结了ENIGMA-OCD正在进行的工作，并考虑了ENIGMA内外强迫症神经影像学研究的未来方向。
Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive–compulsive disorder (OCD). At the same time, neuroimaging studies of OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites have been bolstered by the ENIGMA consortium; this provides specific technical expertise for conducting multi‐site analyses, as well as access to a collaborative community of neuroimaging scientists. In this article, we outline the background to, development of, and initial findings from ENIGMA's OCD working group, which currently consists of 47 samples from 34 institutes in 15 countries on 5 continents, with a total sample of 2,323 OCD patients and 2,325 healthy controls. Initial work has focused on studies of cortical thickness and subcortical volumes, structural connectivity, and brain lateralization in children, adolescents and adults with OCD, also including the study on the commonalities and distinctions across different neurodevelopment disorders. Additional work is ongoing, employing machine learning techniques. Findings to date have contributed to the development of neurobiological models of OCD, have provided an important model of global scientific collaboration, and have had a number of clinical implications. Importantly, our work has shed new light on questions about whether structural and functional alterations found in OCD reflect neurodevelopmental changes, effects of the disease process, or medication impacts. We conclude with a summary of ongoing work by ENIGMA‐OCD, and a consideration of future directions for neuroimaging research on OCD within and beyond ENIGMA.
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影响因子：
11
作者：
Hibar, D. P.;Westlye, L. T.;van Erp, T. G. M.;Rasmussen, J.;Leonardo, C. D.;Faskowitz, J.;Haukvik, U. K.;Hartberg, C. B.;Doan, N. T.;Agartz, I.;Dale, A. M.;Gruber, O.;Kraemer, B.;Trost, S.;Liberg, B.;Abe, C.;Ekman, C. J.;Ingvar, M.;Landen, M.;Fears, S. C.;Freimer, N. B.;Bearden, C. E.;Sprooten, E.;Glahn, D. C.;Pearlson, G. D.;Emsell, L.;Kenney, J.;Scanlon, C.;McDonald, C.;Cannon, D. M.;Almeida, J.;Versace, A.;Caseras, X.;Lawrence, N. S.;Phillips, M. L.;Dima, D.;Delvecchio, G.;Frangou, S.;Satterthwaite, T. D.;Wolf, D.;Houenou, J.;Henry, C.;Malt, U. F.;Boen, E.;Elvsashagen, T.;Young, A. H.;Lloyd, A. J.;Goodwin, G. M.;Mackay, C. E.;Bourne, C.;Bilderbeck, A.;Abramovic, L.;Boks, M. P.;van Haren, N. E. M.;Ophoff, R. A.;Kahn, R. S.;Bauer, M.;Pfennig, A.;Alda, M.;Hajek, T.;Mwangi, B.;Soares, J. C.;Nickson, T.;Dimitrova, R.;Sussmann, J. E.;Hagenaars, S.;Whalley, H. C.;McIntosh, A. M.;Thompson, P. M.;Andreassen, O. A.
通讯作者：
Andreassen, O. A.
影响因子：
4.8
作者：
Adhikari BM;Jahanshad N;Shukla D;Glahn DC;Blangero J;Fox PT;Reynolds RC;Cox RW;Fieremans E;Veraart J;Novikov DS;Nichols TE;Hong LE;Thompson PM;Kochunov P
通讯作者：
Kochunov P
影响因子：
10.5
作者：
Fouche, Jean-Paul;du Plessis, Stefan;van den Heuvel, Odile A.
通讯作者：
van den Heuvel, Odile A.
影响因子：
7.7
作者：
Douw, Linda;Quaak, Mirjam;Vriend, Chris
通讯作者：
Vriend, Chris
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.