A case-control study of cancer of the prostate in Somerset and east Devon.
A case-control study of cancer of the prostate in Somerset and east Devon.
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DOI：
10.1038/bjc.1996.418
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发表时间：
1996-08
影响因子：
8.8
通讯作者：
Bowie, C
中科院分区：
文献类型：
--
作者：
Ewings, P;Bowie, C
在萨默塞特和东德文郡进行了一项病例对照研究，以调查前列腺癌的可能危险因素。总共有159例，在汤顿确诊。耶奥维尔和埃克塞特医院之间的1989年5月和1991年5月，被确定为前瞻性和采访的结构化问卷。共有161名诊断为良性前列腺肥大的男性和164名非泌尿科医院对照者被给予相同的问卷调查。调查问卷涵盖了从以前的研究中确定的广泛因素，但这项研究的中心假设与饮食（脂肪和绿色蔬菜），性活动和农业作为一种职业有关。这项研究发现，农业与前列腺癌风险之间没有关联（比值比= 0.74，95%置信区间0.46-1.18），也与性伴侣数量测量的性活动无关（趋势卡方检验P = 0.52）。性传播疾病史与前列腺癌无显著相关，但涉及的人数很少，比值比为2.06（0.38-11.2）与假设一致。一系列旨在引起膳食脂肪摄入量的问题没有产生显着的关联，尽管肉类消费显示随着消费量的增加风险增加（趋势检验P = 0.005）。多吃叶绿色蔬菜与低风险相关，但不显著（趋势检验P = 0.16）。正如预期的那样，调查了如此多的因素，发现了一些统计学上显著的关联，尽管这些关联只能被视为在此背景下产生的假设。这些因素包括包皮环切术和高鱼类消费的明显保护作用。
A case-control study in Somerset and east Devon was undertaken to investigate possible risk factors for prostatic cancer. A total of 159 cases, diagnosed at Taunton. Yeovil and Exeter hospitals between May 1989 and May 1991, were identified prospectively and interviewed with a structured questionnaire. A total of 161 men diagnosed with benign prostatic hypertrophy and 164 non-urological hospital controls were given identical questionnaires. The questionnaire covered a wide range of factors identified from previous studies, but the central hypotheses for this study related to diet (fat and green vegetables), sexual activity and farming as an occupation. This study found no association between farming and risk of prostatic cancer (odds ratio = 0.74, 95% confidence interval 0.46-1.18), nor with sexual activity as measured by number of sexual partners (chi-squared test for trend P = 0.52). A history of sexually transmitted disease was not significantly associated with prostatic cancer, but the numbers involved were very small and the odds ratio of 2.06 (0.38-11.2) is consistent with the hypothesis. A range of questions aimed at eliciting dietary fat intake produced no significant associations, although meat consumption showed increasing risk with increasing consumption (test for trend P = 0.005). Increased consumption of leafy green vegetables was associated with lower risk, but not significantly so (test for trend P = 0.16). As expected with so many factors investigated, some statistically significant associations were found, although these can only be viewed as hypothesis generating in this context. These included apparent protective effects of circumcision and high fish consumption.
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影响因子：
2.8
作者：
MISHINA, T;WATANABE, H;NAKAO, M
通讯作者：
NAKAO, M
影响因子：
2.8
作者：
ROSS, RK;PAGANINIHILL, A;HENDERSON, BE
通讯作者：
HENDERSON, BE
影响因子：
2.3
作者：
SIDNEY, S;QUESENBERRY, CP;CATTOLICA, EV
通讯作者：
CATTOLICA, EV
影响因子：
120.7
作者：
GIOVANNUCCI, E;ASCHERIO, A;WILLETT, WC
通讯作者：
WILLETT, WC
影响因子：
120.7
作者：
GIOVANNUCCI, E;TOSTESON, TD;COLDITZ, GA
通讯作者：
COLDITZ, GA