Genetic Models of Leukemia in Zebrafish.

Genetic Models of Leukemia in Zebrafish.
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DOI:
10.3389/fcell.2018.00115
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发表时间:
2018
影响因子:
5.5
通讯作者:
de Jong JLO
de Jong JLO
中科院分区:
生物学2区
文献类型:
--
作者:
Baeten JT;de Jong JLO

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斑马鱼动物模型作为研究人类疾病的工具越来越受欢迎。在过去的15年里,在斑马鱼中开发了许多白血病和其他血液恶性肿瘤的模型。这些赋予了一些显着的优势,在其他动物和系统中的类似模型,代表了一个强大的资源,人类白血病的分子基础的调查。这篇综述讨论了各种斑马鱼模型的淋巴细胞和髓细胞白血病,主要的发现,已经成为可能,并为未来的探索机会。
The zebrafish animal model is gaining increasing popularity as a tool for studying human disease. Over the past 15 years, many models of leukemia and other hematological malignancies have been developed in the zebrafish. These confer some significant advantages over similar models in other animals and systems, representing a powerful resource for investigation of the molecular basis of human leukemia. This review discusses the various zebrafish models of lymphoid and myeloid leukemia available, the major discoveries that have been made possible by them, and opportunities for future exploration.
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