Chemical foundations of hydrogen sulfide biology.
Chemical foundations of hydrogen sulfide biology.
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DOI：
10.1016/j.niox.2013.07.001
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发表时间：
2013-11-30
期刊：
影响因子：
--
通讯作者：
Lancaster JR Jr
中科院分区：
文献类型：
--
作者：
Li Q;Lancaster JR Jr
继一氧化氮（一氧化二氮）和一氧化碳之后，硫化氢（或其较新的系统名称硫化氢，H2S）成为第三种根据浓度既有毒又有益的小分子。尽管它具有令人印象深刻的治疗潜力，但其有益作用的潜在机制尚不清楚。任何新的机制都必须遵守基本的化学原理。早在发现H2S的生物学相关性之前，人们就对其进行了研究，然而，除了少数例外，这些过去的工作在探索H2S生物学功能的机制难题的道路上受到的关注相对较少。本文介绍了H2S的基本物理和化学性质，重点介绍了H2S及其三种潜在生物靶标（氧化剂、金属和硫醇衍生物）之间的化学关系，讨论了这些基础知识在H2S生物学和方法中的应用，并介绍了这一新兴领域的标准术语。
Following nitric oxide (nitrogen monoxide) and carbon monoxide, hydrogen sulfide (or its newer systematic name sulfane, H2S) became the third small molecule that can be both toxic and beneficial depending on the concentration. In spite of its impressive therapeutic potential, the underlying mechanisms for its beneficial effects remain unclear. Any novel mechanism has to obey fundamental chemical principles. H2S chemistry was studied long before its biological relevance was discovered, however, with a few exceptions, these past works have received relatively little attention in the path of exploring the mechanistic conundrum of H2S biological functions. This review calls attention to the basic physical and chemical properties of H2S, focuses on the chemistry between H2S and its three potential biological targets: oxidants, metals and thiol derivatives, discusses the applications of these basics into H2S biology and methodology, and introduces the standard terminology to this youthful field.
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