Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patients with Alzheimer disease, mild cognitive impairment, and healthy controls.
Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patients with Alzheimer disease, mild cognitive impairment, and healthy controls.
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DOI：
10.1177/0891988710363715
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发表时间：
2010-09
影响因子：
2.6
通讯作者：
Parsey RV
中科院分区：
文献类型：
--
作者：
Devanand DP;Mikhno A;Pelton GH;Cuasay K;Pradhaban G;Dileep Kumar JS;Upton N;Lai R;Gunn RN;Libri V;Liu X;van Heertum R;Mann JJ;Parsey RV
在轻度阿尔茨海默病（AD，n=18）、轻度认知功能障碍（MCI，n=24）和对照组（CTR，n = 18）中，使用11 C-PIB PET和使用18F-FDG PET评估脑中淀粉样蛋白负荷和脑葡萄糖代谢。与CTR或MCI相比，AD患者的前额叶皮层、扣带回、顶叶皮层和楔前叶中的11 C-PIB结合电位（BPND）较高，而MCI患者的前额叶皮层中的11 C-PIB结合电位高于CTR。对于18F-FDG，与CTR和MCI相比，AD的楔前叶和顶叶皮质中的rCMRGlu降低，而MCI-CTR无差异。对于AD-CTR比较，楔前叶BPND ROC曲线下面积（AUC）为0.938，顶叶皮质rCMRGlu AUC为0.915;对于组合AUC为0.989。11 C-PIB PET BPND可明确区分诊断组，与18F-FDG PET rCMRGlu结合，这种效果更强。这些PET技术提供了补充信息，在横向比较中强烈区分诊断组，需要在纵向研究中进行测试。
Amyloid load in the brain using 11C-PIB PET and cerebral glucose metabolism using 18F-FDG PET were evaluated in patients with mild Alzheimer’s disease (AD, n=18), mild cognitive impairment (MCI, n=24) and controls (CTR, n=18). 11C-PIB binding potential (BPND) was higher in prefrontal cortex, cingulate, parietal cortex, and precuneus in AD compared to CTR or MCI, and in prefrontal cortex for MCI compared to CTR. For 18F-FDG, rCMRGlu was decreased in precuneus and parietal cortex in AD compared to CTR and MCI, with no MCI-CTR differences. For the AD-CTR comparison, precuneus BPND area under the ROC curve (AUC) was 0.938 and parietal cortex rCMRGlu AUC was 0.915; for the combination AUC was 0.989. 11C-PIB PET BPND clearly distinguished diagnostic groups, and combined with 18F-FDG PET rCMRGlu this effect was stronger. These PET techniques provide complementary information in strongly distinguishing diagnostic groups in cross-sectional comparisons that need testing in longitudinal studies.
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影响因子：
9.9
作者：
Kemppainen, N. M.;Aalto, S.;Rinne, J. O.
通讯作者：
Rinne, J. O.
DOI：
10.1073/pnas.92.8.3586
发表时间：
1995-04-11
影响因子：
11.1
作者：
HYMAN, BT;WEST, HL;STANLEY, HE
通讯作者：
STANLEY, HE
影响因子：
9.9
作者：
Jagust, W. J.;Landau, S. M.;Mathis, C. A.
通讯作者：
Mathis, C. A.
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B