Dopamine modulates novelty seeking behavior during decision making.
Dopamine modulates novelty seeking behavior during decision making.
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DOI：
10.1037/a0037128
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发表时间：
2014-10
影响因子：
1.9
通讯作者：
Averbeck BB
中科院分区：
文献类型：
--
作者：
Costa VD;Tran VL;Turchi J;Averbeck BB
新奇探索是指人类和动物探索新的和陌生的刺激和环境的倾向。有证据表明，新的刺激可以兴奋多巴胺神经元，激活接受多巴胺能输入的大脑区域，这支持了多巴胺调节新奇寻求的想法。此外，多巴胺被证明可以在新的环境中驱动探索性行为。目前尚不清楚，当多巴胺被定义为探索新选择与开发熟悉的选择时，它是否会促进新奇寻求。为了验证这一假设，我们给猴子全身注射生理盐水或选择性多巴胺转运体(DAT)抑制剂GBR-12909，并评估它们在概率决策任务中的新奇寻找行为。这项任务包括对新的选择选项的伪随机介绍。这让猴子们有机会探索新的选择，或者利用他们已经尝试过的熟悉的选择。我们发现，阻断DAT增加了猴子对新选项的偏好。符合猴子选择数据的强化学习(RL)模型表明，在DAT封锁后，猴子寻求新奇事物的增加是由猴子分配给新选项的初始值的增加推动的。然而，阻断DAT并没有调节猴子学习哪些线索最能预测奖励或它们利用这一知识的倾向的速度。这些数据表明，多巴胺提高了新奇驱动的价值，并暗示过度追求新奇--冲动和行为成瘾的特征--可能是由于较少的再吸收而导致的多巴胺增加所致。
Novelty seeking refers to the tendency of humans and animals to explore novel and unfamiliar stimuli and environments. The idea that dopamine modulates novelty seeking is supported by evidence that novel stimuli excite dopamine neurons and activate brain regions receiving dopaminergic input. In addition, dopamine is shown to drive exploratory behavior in novel environments. It is not clear whether dopamine promotes novelty seeking when it is framed as the decision to explore novel options vs. the exploitation of familiar options. To test this hypothesis, we administered systemic injections of saline or GBR-12909, a selective dopamine transporter (DAT) inhibitor, to monkeys and assessed their novelty seeking behavior during a probabilistic decision making task. The task involved pseudorandom introductions of novel choice options. This allowed monkeys the opportunity to explore novel options or to exploit familiar options that they had already sampled. We found that DAT blockade increased the monkeys’ preference for novel options. A reinforcement learning (RL) model fit to the monkeys’ choice data showed that increased novelty seeking following DAT blockade was driven by an increase in the initial value the monkeys assigned to novel options. However, blocking DAT did not modulate the rate at which the monkeys learned which cues were most predictive of reward or their tendency to exploit that knowledge. These data demonstrate that dopamine enhances novelty-driven value and imply that excessive novelty seeking—characteristic of impulsivity and behavioral addictions—might be caused by increases in dopamine, stemming from less reuptake.
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影响因子：
3
作者：
Asaad, Wael F.;Eskandar, Emad N.
通讯作者：
Eskandar, Emad N.
DOI：
10.1098/rstb.2007.2098
发表时间：
2007-05-29
影响因子：
6.3
作者：
Cohen, Jonathan D.;McClure, Samuel M.;Yu, Angela J.
通讯作者：
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影响因子：
25
作者：
Kreek, MJ;Nielsen, DA;LaForge, KS
通讯作者：
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影响因子：
6
作者：
Chang, Linda;Alicata, Daniel;Volkow, Nora
通讯作者：
Volkow, Nora
影响因子：
1.9
作者：
Averbeck, Bruno B.;Djamshidian, Atbin;Roiser, Jonathan P.
通讯作者：
Roiser, Jonathan P.