Tone-detection training enhances spectral integration mediated by intracortical pathways in primary auditory cortex.
Tone-detection training enhances spectral integration mediated by intracortical pathways in primary auditory cortex.
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DOI：
10.1016/j.nlm.2013.01.006
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发表时间：
2013-03
影响因子：
2.7
通讯作者：
Metherate R
中科院分区：
文献类型：
--
作者：
Guo F;Intskirveli I;Blake DT;Metherate R
听觉提示行为训练可以改变初级听觉皮层（A1）的神经回路，但经验依赖性皮层可塑性的机制和后果尚未完全了解。为了解决这个问题，我们训练成年老鼠检测 5 kHz 目标以获得食物奖励。经过 14 天的训练，我们在 A1 内确定了三个位置：i) 代表特征频率 (CF) 5 kHz 的区域，ii) CF 约为 10 kHz 的附近区域，以及 iii) CF 约为 20 kHz 的较远区域。为了比较 A1 中接近和远离目标频率表示的功能连接性，我们在中频 (~10 kHz) 和高频 (~20 kHz) CF 区域放置了一个 16 通道多探头，并获得了由一系列音调刺激（CF ± 1-3 个八度音程，以四分之一倍频程为步长）引起的电流源密度 (CSD) 曲线。我们的目标是构建“CSD 感受野”（CSD RF），以确定音调诱发电流汇的层流和频谱轮廓，并推断丘脑皮质和皮质内输入的变化。与未经训练的对照动物中的 CSD RF 相比，行为训练改变了 10 kHz 处的 CSD RF，但没有改变 20 kHz 处的 CSD RF。在 10 kHz 站点，目标频率引起的电流吸收在第 2/3 层中得到增强，但第 4 层中的初始电流吸收没有改变。结果表明，训练引起的可塑性沿着连接目标表征与附近皮质区域的皮质内通路。最后，我们将个体动物的行为表现（敏感性指数，d'）与 CSD 反应联系起来，并发现训练期间 d' 的发展与 2/3 层目标诱发电流吸收的幅度之间存在显着相关性。结果表明，皮质内通路的可塑性对于听觉学习很重要。
Auditory-cued behavioral training can alter neural circuits in primary auditory cortex (A1), but the mechanisms and consequences of experience-dependent cortical plasticity are not fully understood. To address this issue, we trained adult rats to detect a 5 kHz target in order to receive a food reward. After 14 days training we identified three locations within A1: i) the region representing the characteristic frequency (CF) 5 kHz, ii) a nearby region with CF ~10 kHz, and iii) a more distant region with CF ~20 kHz. In order to compare functional connectivity in A1 near to, vs. far from, the representation of the target frequency, we placed a 16-channel multiprobe in middle- (~10 kHz) and high- (~20 kHz) CF regions and obtained current-source density (CSD) profiles evoked by a range of tone stimuli (CF ± 1–3 octaves in quarter-octave steps). Our aim was to construct “CSD receptive fields” (CSD RFs) in order to determine the laminar and spectral profile of tone-evoked current sinks, and infer changes to thalamocortical and intracortical inputs. Behavioral training altered CSD RFs at the 10 kHz, but not 20 kHz, site relative to CSD RFs in untrained control animals. At the 10 kHz site, current sinks evoked by the target frequency were enhanced in layer 2/3, but the initial current sink in layer 4 was not altered. The results imply training-induced plasticity along intracortical pathways connecting the target representation with nearby cortical regions. Finally, we related behavioral performance (sensitivity index, d′) to CSD responses in individual animals, and found a significant correlation between the development of d′ over training and the amplitude of the target-evoked current sink in layer 2/3. The results suggest that plasticity along intracortical pathways is important for auditory learning.
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影响因子：
2
作者：
Edeline, JM
通讯作者：
Edeline, JM
影响因子：
2.5
作者：
Blake, DT;Strata, F;Merzenich, MM
通讯作者：
Merzenich, MM
DOI：
10.1073/pnas.092278099
发表时间：
2002-07-23
影响因子：
11.1
作者：
Blake, DT;Strata, F;Merzenich, MM
通讯作者：
Merzenich, MM
影响因子：
25
作者：
Kawai, Hideki;Lazar, Ronit;Metherate, Raju
通讯作者：
Metherate, Raju
影响因子：
2.5
作者：
Kaur, S;Lazar, R;Metherate, R
通讯作者：
Metherate, R