Fatty acid desaturation index correlates with body mass and adiposity indices of obesity in Wistar NIN obese mutant rat strains WNIN/Ob and WNIN/GR-Ob.
Fatty acid desaturation index correlates with body mass and adiposity indices of obesity in Wistar NIN obese mutant rat strains WNIN/Ob and WNIN/GR-Ob.
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DOI：
10.1186/1743-7075-6-27
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发表时间：
2009-06-11
影响因子：
4.5
通讯作者：
Vajreswari A
中科院分区：
文献类型：
--
作者：
Jeyakumar SM;Lopamudra P;Padmini S;Balakrishna N;Giridharan NV;Vajreswari A
微粒体硬脂酰辅酶A去饱和酶1（SCD 1）是参与单不饱和脂肪酸（MUFA）生物合成的限速酶;棕榈油酸（16：1）和油酸（18：1）从其各自的底物棕榈酸（16：0）和硬脂酸（18：0）。18：1至18：0的比例与调节膜流动性和功能有关。SCD 1在肥胖人类以及啮齿动物模型中大量表达。然而，没有研究将脂肪酸去饱和指数（16：1/16：0和18：1/18：0），SCD 1活性的指标与肥胖的标志物体重指数（BMI）和肥胖指数（AI）相关。因此，在这里，我们试图将脂肪酸去饱和指数与Wistar NIN-肥胖突变大鼠品系（即WNIN/Ob和WNIN/GR-Ob（糖耐量受损））的BMI和AI联系起来。为此，取200日龄两种品系的雄性6只瘦大鼠和6只肥胖大鼠。分析血浆、各种组织如肝脏、白色脂肪组织（腹膜后、附睾、网膜和皮下）和棕色脂肪组织中的脂肪酸组成。脂肪酸组成数据显示，棕榈油酸（16：1）和油酸（18：1）水平显着增加，这反映在增加的去饱和指数（16：1/16：0和18：1/18：0）在血浆和所有组织的肥胖大鼠，当与各自的年龄和性别匹配的瘦大鼠。此外，我们发现去饱和指数，BMI和AI之间的血浆和大多数分析的组织强正相关。到目前为止，血浆Δ 9去饱和指数与高脂血症有很好的相关性，并且我们通过采用两种肥胖模型，即WNIN/Ob和WNIN/GR-Ob，已经显示血浆Δ 9去饱和指数与肥胖的物理标志物如BMI和AI相关。总之，Δ 9去饱和指数可作为评估肥胖程度和治疗/营养干预对抗肥胖的影响的潜在敏感生化标志物，沿着其他指标。
Microsomal stearoyl-CoA desaturase1 (SCD1) is the rate limiting enzyme involved in the biosynthesis of monounsaturated fatty acids (MUFAs); palmitoleic (16:1) and oleic (18:1) acid from their respective substrates palmitic (16:0) and stearic (18:0) acids. The ratio of 18:1 to 18:0 has been implicated in the regulation membrane fluidity and function. SCD1 is abundantly expressed in obese humans as well as rodent models. However, no studies have correlated the fatty acid desaturation index (16:1/16:0 and 18:1/18:0), an indicator of SCD1 activity with the markers of obesity in terms of body mass index (BMI) and adiposity index (AI). Therefore, here, we attempted to relate the fatty acid desaturation index with BMI and AI in Wistar NIN-obese mutant rat strains namely, WNIN/Ob and WNIN/GR-Ob (with impaired glucose tolerance). For this purpose, 200 days old male 6 lean and 6 obese rats of both strains were taken. Fatty acid composition was analyzed in plasma, various tissues such as liver, white adipose tissues (retroperitoneal, epididymal, omental, and subcutaneous) and brown adipose tissue. Fatty acid composition data showed significant increase in palmitoleic (16:1) and oleic (18:1) acid levels, which were reflected in increased desaturation index (16:1/16:0 and 18:1/18:0) in plasma and all the tissues of obese rats of both strains, when compared with their respective age and sex-matched lean rats. Further, we found a strong positive correlation between desaturation index, BMI and AI in plasma and most of the tissues analyzed. So far, plasma Δ9 desaturation index has been well correlated with hypertriglyceridemia and we, by employing two models of obesity namely, WNIN/Ob and WNIN/GR-Ob, have shown Δ9 desaturation index of plasma correlated with physical markers of obesity such as BMI and AI. In conclusion, Δ9 desaturation index may serve as a potential sensitive biochemical marker to assess the degree of obesity and impact of therapeutic/nutritional interventions to combat obesity, along with other indicators.
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影响因子：
6.5
作者：
Attie, AD;Krauss, RM;Ntambi, JM
通讯作者：
Ntambi, JM
DOI：
10.1161/atvbaha.107.160150
发表时间：
2008-06-01
影响因子：
8.7
作者：
Mar-Heyming, Rebecca;Miyazaki, Makoto;Lusis, Aldons J.
通讯作者：
Lusis, Aldons J.
影响因子：
29
作者：
Hulver, MW;Berggren, JR;Muoio, DM
通讯作者：
Muoio, DM
DOI：
10.1016/j.bbrc.2008.03.073
发表时间：
2008-05-30
影响因子：
3.1
作者：
Jeyakumar, S. M.;Vajreswari, A.;Giridharan, N. V.
通讯作者：
Giridharan, N. V.
影响因子：
5.3
作者：
Sheril, Alex;Jeyakumar, Shanmugam M.;Vajreswari, Ayyalasomayajula
通讯作者：
Vajreswari, Ayyalasomayajula