Reversible reactivity by optic nerve astrocytes.
Reversible reactivity by optic nerve astrocytes.
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DOI：
10.1002/glia.22507
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发表时间：
2013-08
期刊：
影响因子：
6.2
通讯作者：
Jakobs, Tatjana C.
中科院分区：
文献类型：
--
作者：
Sun, Daniel;Qu, Juan;Jakobs, Tatjana C.
反应性星形胶质细胞通常在对轴突、神经元细胞体和胶质细胞造成不可逆机械损伤的模型中进行研究。在这里，我们评估了视神经头星形胶质细胞对短暂轻度眼压升高引起的轻微损伤的反应。星形胶质细胞表现出反应性重塑，在第三天达到顶峰，表现出肥大、突起收缩和形状简化。这并没有伴随着基因表达谱的任何显著变化。电子显微镜和正常的顺行和逆行运输证明，视神经轴突在任何时候都没有明显的损伤。值得注意的是，形态重塑是可逆的。这些发现强调了反应性的可塑性。他们表明，如果损伤被移除，反应性可以完全消除，并表明反应性本身并不一定对轴突有害。这种反应可能代表了最终导致神经胶质瘢痕形成的一系列早期事件。
Reactive astrocytes are typically studied in models that cause irreversible mechanical damage to axons, neuronal cell bodies, and glia. Here, we evaluated the response of astrocytes in the optic nerve head to a subtle injury induced by a brief, mild elevation of the intraocular pressure. Astrocytes demonstrated reactive remodeling that peaked at three days, showing hypertrophy, process retraction and simplification of their shape. This was not accompanied by any significant changes in the gene expression profile. At no time was there discernible damage to the optic axons, as evidenced by electron microscopy and normal anterograde and retrograde transport. Remarkably, the morphological remodeling was reversible. These findings underscore the plastic nature of reactivity. They show that reactivity can resolve fully if the insult is removed, and suggest that reactivity per se is not necessarily deleterious to axons. This reaction may represent very early events in the sequence that eventually leads to glial scarring.
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影响因子：
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DOI：
10.1073/pnas.0808698106
发表时间：
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影响因子：
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作者：
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