The mitohormetic response as part of the cytoprotection mechanism of berberine
The mitohormetic response as part of the cytoprotection mechanism of berberine
复制标题
线粒体激素反应是小檗碱细胞保护机制的一部分
DOI：
10.1186/s10020-020-0136-8
复制
发表时间：
2020-01
影响因子：
5.7
通讯作者：
Xiaofang Guo
中科院分区：
文献类型：
--
作者：
Xiaofei Zhu;Yihui Wei;Beibei Yang;Xiaoxiao Yin;Xiaofang Guo
黄连素是从天然植物黄连中提取的一种重要的生物活性成分，在我国具有抗糖尿病的作用。其他类型的药理学活性，如抗炎，抗菌，降血脂和抗癌作用，也进行了检查。在细胞水平上，这些药理活性主要是抑制作用。然而，在各种类型的细胞中也观察到小檗碱的细胞保护作用，例如神经元、内皮细胞、成纤维细胞和β细胞。这种矛盾的结果可能与小檗碱在细胞内的分布和特性密切相关，并且它们可以用一种特殊形式的兴奋效应--有丝分裂兴奋效应来机械地解释。本文综述了小檗碱诱导的有丝分裂反应，并对其可能的信号通路进行了评价。这些结果可能有助于更好地临床应用黄连素，并提示在临床应用中应谨慎考虑一些以黄连素为靶点的常规药物。
It was well-known that Berberine, a major bioactive compound extracted from natural plants Coptis chinensis, has anti-diabetic effects for decades in china. Other types of pharmacological activities, such as anti-inflammatory, antimicrobial, hypolipidemic, and anti-cancer effects, have also been examined. At cellular level, these pharmacological activities were mostly an inhibitory effect. However, the cytoprotective effect of berberine was also observed in various types of cells, such as neurons, endothelial cells, fibroblasts, and β-cells. The paradoxical result may be closely associated with characteristics and distribution of berberine within cells, and they can be explained mechanically by mitohormesis, one particular form of hormesis. Here, we reviewed the mitohormetic response and assessed the berberine-induced effects and the possible signaling pathway involved. These findings may contribute to better clinical applications of berberine and indicate that some mitochondria-targeted conventional drugs should be considered carefully in clinical application.
登录
查看更多内容
影响因子：
16.6
作者：
Obata F;Fons CO;Gould AP
通讯作者：
Gould AP
影响因子：
2.9
作者：
Truong TH;Carroll KS
通讯作者：
Carroll KS
AMP激活的蛋白激酶对ULK1（HATG1）的磷酸化将能量传感连接到线粒体。
DOI：
10.1126/science.1196371
发表时间：
2011-01-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Egan DF;Shackelford DB;Mihaylova MM;Gelino S;Kohnz RA;Mair W;Vasquez DS;Joshi A;Gwinn DM;Taylor R;Asara JM;Fitzpatrick J;Dillin A;Viollet B;Kundu M;Hansen M;Shaw RJ
通讯作者：
Shaw RJ
影响因子：
5.3
作者：
Zhang ZY;Zhang Z;Fauser U;Schluesener HJ
通讯作者：
Schluesener HJ
影响因子：
8.8
作者：
Moullan N;Mouchiroud L;Wang X;Ryu D;Williams EG;Mottis A;Jovaisaite V;Frochaux MV;Quiros PM;Deplancke B;Houtkooper RH;Auwerx J
通讯作者：
Auwerx J