Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila.
Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila.
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DOI：
10.1038/s41467-018-03070-w
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发表时间：
2018-03-07
影响因子：
16.6
通讯作者：
Gould AP
中科院分区：
文献类型：
--
作者：
Obata F;Fons CO;Gould AP
在发展过程中经历的环境压力对健康和疾病产生许多长期影响。例如，化学氧化剂或遗传扰动诱导低水平的活性氧可以延长几个物种的寿命。在某些情况下，低剂量氧化剂的有益作用归因于适应性保护机制，如有丝分裂，这涉及应激反应基因表达的长期增加。在这里，我们在果蝇中表明，在发育过程中短暂暴露于低浓度的氧化剂会导致成年寿命的延长。令人惊讶的是，这取决于氧化剂以类似抗生素的方式选择性地消耗醋杆菌属变形菌的微生物组。我们证明了醋杆菌属的存在，如A。在本地微生物群中，乙酰丙酮增加了与年龄相关的肠道功能障碍，缩短了寿命。这项研究表明，生命早期的低剂量氧化剂暴露可以通过微生物组重塑而不是线粒体兴奋来延长寿命。低剂量的有害化学物质，如氧化剂，可以产生有益的影响，在某些情况下，通过增加应激反应基因的表达来介导。在这项研究中，作者表明，低剂量的氧化剂通过不同的机制增加果蝇的寿命，重塑微生物组。
Environmental stresses experienced during development exert many long-term effects upon health and disease. For example, chemical oxidants or genetic perturbations that induce low levels of reactive oxygen species can extend lifespan in several species. In some cases, the beneficial effects of low-dose oxidants are attributed to adaptive protective mechanisms such as mitohormesis, which involve long-term increases in the expression of stress response genes. Here we show in Drosophila that transient exposure to low concentrations of oxidants during development leads to an extension of adult lifespan. Surprisingly, this depends upon oxidants acting in an antibiotic-like manner to selectively deplete the microbiome of Acetobacter proteobacteria. We demonstrate that the presence of Acetobacter species, such as A. aceti, in the indigenous microbiota increases age-related gut dysfunction and shortens lifespan. This study demonstrates that low-dose oxidant exposure during early life can extend lifespan via microbiome remodelling rather than mitohormesis. Low doses of harmful chemicals such as oxidants can have beneficial effects, in some cases mediated by increased expression of stress response genes. In this study, the authors show that low-dose oxidants increase the longevity of Drosophila via a different mechanism, remodelling of the microbiome.
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影响因子：
3.7
作者：
Erkosar B;Defaye A;Bozonnet N;Puthier D;Royet J;Leulier F
通讯作者：
Leulier F
影响因子：
8.8
作者：
Clark RI;Salazar A;Yamada R;Fitz-Gibbon S;Morselli M;Alcaraz J;Rana A;Rera M;Pellegrini M;Ja WW;Walker DW
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3.7
作者：
Fridmann-Sirkis Y;Stern S;Elgart M;Galili M;Zeisel A;Shental N;Soen Y
通讯作者：
Soen Y
影响因子：
3.5
作者：
Langley-Evans, Simon C.;Sculley, Dean V.
通讯作者：
Sculley, Dean V.
影响因子：
64.5
作者：
Bailey AP;Koster G;Guillermier C;Hirst EM;MacRae JI;Lechene CP;Postle AD;Gould AP
通讯作者：
Gould AP