Lactation-associated infertility in Japanese monkeys (Macaca fuscata) during the breeding season
Lactation-associated infertility in Japanese monkeys (Macaca fuscata) during the breeding season
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日本猴（Macaca fuscata）在繁殖季节与哺乳相关的不孕症
作者：
M. Kondo;H. Kishi;C. Kojima;W. Jin;J. Suzuki;K. Shimizu;M. Itoh;S. Ohkura;H. Tsukamura;K. Maeda;G. Watanabe;K. Taya
为探讨日本猕猴(Macaca Fuscata)在产后第一个生殖季节(产后150~360d)抑制发情周期的内分泌因素，取外周血测定血浆卵泡刺激素、黄体生成素、孕酮、雌二醇-17β、免疫抑制素和皮质醇的浓度。结果表明，在哺乳期日本猴的血液循环中，促卵泡刺激素(FSH1.7~2.7pg/ml)、促黄体生成素(308.5~461.0 pg/ml)、17雌二醇(β)(62.6pg/ml)和孕酮(145.0~453.0 pg/ml)的循环浓度较低，接近正常月经周期和非繁殖期的最低值。雌性日本猴卵泡和黄体分泌的ir-抑制素浓度也很低(300.5-585.0 pg/ml)。这强烈地表明，在哺乳期没有发生卵泡发育。哺乳期血清皮质醇浓度(261.0-519 ng/ml)高于非繁殖期。由于研究期间经常看到婴儿在哺乳他们的母亲，结果表明皮质醇水平的增加与哺乳诱导的促肾上腺皮质激素释放激素(CRH)和促肾上腺皮质激素(ACTH)的分泌有关。这项研究的结果表明，日本哺乳猴产后长期不孕，明显抑制卵泡生长和无排卵，是由于促性腺激素刺激较弱，这可能是哺乳刺激的结果。动物园生物22：65-76,2003。©2003 Wiley-Liss公司
To investigate the endocrine factors in Japanese monkeys (Macaca fuscata) responsible for the suppression of the estrous cycle during the first reproductive season after delivery (150–360 days postpartum), peripheral blood was taken to measure plasma concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone, estradiol-17β, immunoreactive (ir)-inhibin, and cortisol. The results demonstrated that during the breeding season of lactating Japanese monkeys, circulating concentrations of FSH (1.7–2.7 ng/ml), LH (308.5–461.0 pg/ml), estradiol-17β (<62.6 pg/ml), and progesterone (145.0–453.0 pg/ml) remained low and were similar to the nadir levels observed during both the normal menstrual cycles and the nonbreeding season. Concentrations of ir-inhibin, which is secreted from both follicles and corpus luteum in female Japanese monkeys, were also low (300.5–585.0 pg/ml). This strongly suggests that no follicular development occurs during lactation. Serum concentrations of cortisol (261.0–519 ng/ml) were higher during lactation than during the nonbreeding season. Since babies were often seen suckling their mothers during the study, the results indicate that the increased cortisol levels were associated with suckling-induced secretion of corticotrophin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH). The results of this study indicate that a long period of postpartum infertility in lactating Japanese monkeys, with apparent inhibition of follicle growth and anovulation, is due to weak gonadotropin stimulation, which may occur as the result of a suckling stimulus. Zoo Biol 22:65–76, 2003. © 2003 Wiley-Liss, Inc.
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恒河猴的促肾上腺皮质激素释放因子和促性腺激素释放激素脉冲发生器活性。
影响因子：
4.1
作者：
Williams,CL;Nishihara,M;Thalabard,JC;Grosser,PM;Hotchkiss,J;Knobil,E
通讯作者：
Knobil,E
非人类灵长类动物的哺乳期无排卵：限制哺乳会抑制 Prl 分泌，但不会促使食蟹猴恢复排卵月经周期。
影响因子：
2.9
作者：
Gordon,K;Aso,T;Williams,RF
通讯作者：
Williams,RF
哺乳确实会影响棉顶狨猴（Saguinus oedipus）产后到排卵间隔的持续时间。
DOI：
10.1530/jrf.0.0900563
发表时间：
1990
期刊：
Journal of reproduction and fertility
影响因子：
--
作者：
Ziegler,TE;Widowski,TM;Larson,ML;Snowdon,CT
通讯作者：
Snowdon,CT
哺乳对雌性恒河猴（Macaca mulatta）促性腺激素分泌的影响。
影响因子：
3.6
作者：
Plant,TM;Schallenberger,E;Hess,DL;McCormack,JT;Dufy-Barbe,L;Knobil,E
通讯作者：
Knobil,E