The laboratory mouse and wild immunology

The laboratory mouse and wild immunology
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实验室小鼠和野生免疫学

DOI:
10.1111/pim.12150
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发表时间:
2015
影响因子:
2.2
通讯作者:
Viney M
Viney M
中科院分区:
医学4区
文献类型:
--
作者:
Viney M

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实验室小鼠,小家鼠,一直是非常成功的哺乳动物免疫学实验室研究的主力。这些发现哺乳动物免疫系统如何工作的研究,使得野生免疫学领域得以发展,该领域正在寻求了解野生动物的免疫反应如何有助于动物的健康。值得注意的是,几乎没有任何关于野生小家鼠(或另一种常见的实验室模型大鼠)的免疫学研究,但一般的发现是,这些野生动物比它们的实验室驯化对照动物更具免疫反应。这种差异可能反映了这些野生捕获动物先前暴露于抗原的程度相对较高。目前,实验室小鼠免疫学在野生免疫学领域取得重大进展的前景非常好。
The laboratory mouse,Mus musculus domesticus, has been the workhorse of the very successful laboratory study of mammalian immunology. These studies – discovering how the mammalian immune system can work – have allowed the development of the field of wild immunology that is seeking to understand how the immune responses of wild animals contributes to animals' fitness. Remarkably, there have hardly been any studies of the immunology of wildM. musculus domesticus(or of rats, another common laboratory model), but the general finding is that these wild animals are more immunologically responsive, compared with their laboratory domesticated comparators. This difference probably reflects the comparatively greater previous exposure to antigens of these wild‐caught animals. There are now excellent prospects for laboratory mouse immunology to make major advances in the field of wild immunology.
雄性棉鼠(Sigmodon hispidus)对食物补充剂和蛋氨酸的免疫功能和血液学反应。
DOI: 10.1016/s1095-6433(03)00209-5
发表时间: 2003
期刊: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
影响因子: --
作者:
R. E. Webb;D. M. Leslie;R. Lochmiller;R. E. Masters
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DOI: 10.1111/j.1095-8312.2005.00438.x
发表时间: 2005-03-01
影响因子: 1.9
作者:
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通讯作者: Scriven, PN
野生小鼠品系,是研究 B 细胞反应的有价值的模型。
DOI: 10.1016/j.molimm.2008.07.027
发表时间: 2009
影响因子: 3.6
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DOI: 10.2307/1936584
发表时间: 1978
期刊: Ecology
影响因子: 4.8
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通讯作者: G. Barrett
DOI: 10.1017/s0031182000046382
发表时间: 1973-01-01
期刊: PARASITOLOGY
影响因子: 2.4
作者:
BEHNKE, JM;WAKELIN, D
通讯作者: WAKELIN, D