Two cell populations participate in clearance of damaged hair cells from the sensory epithelia of the inner ear.
Two cell populations participate in clearance of damaged hair cells from the sensory epithelia of the inner ear.
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DOI：
10.1016/j.heares.2017.04.006
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发表时间：
2017-09
期刊：
影响因子：
2.8
通讯作者：
Warchol ME
中科院分区：
文献类型：
--
作者：
Hirose K;Rutherford MA;Warchol ME
耳蜗和前庭器官由常驻巨噬细胞填充，但它们在内耳维护和病理中的作用尚不完全清楚。驻留在其他器官的巨噬细胞负责吞噬受伤或感染的细胞，内耳的巨噬细胞可能也起着类似的作用。毛细胞损伤导致巨噬细胞在内耳受损区域附近聚集，要么通过离开血管系统进入迷路，要么通过驻留的巨噬细胞通过局部运动重新组织到损伤区域。在几种情况下观察到巨噬细胞吞噬了凋亡的毛细胞的直接证据。在这里，我们回顾了组织巨噬细胞吞噬感觉上皮损伤毛细胞的证据，以及一些新的实验，这些实验是作为原创工作提出的。一些研究还表明，巨噬细胞并不是内耳唯一的粒细胞，但感觉上皮的支持细胞在清除碎片方面也发挥着重要作用。我们描述了内耳感觉上皮适应的各种方式，以消除受损和死亡的细胞。驻留和迁徙的巨噬细胞以及邻近的支持细胞之间的协作努力导致快速有效地清除细胞碎片，即使在毛细胞迅速和完全丧失的情况下也是如此。
The cochlea and the vestibular organs are populated by resident macrophages, but their role in inner ear maintenance and pathology is not entirely clear. Resident macrophages in other organs are responsible for phagocytosis of injured or infected cells, and it is likely that macrophages in the inner ear serve a similar role. Hair cell injury causes macrophages to accumulate within proximity of damaged regions of the inner ear, either by exiting the vasculature and entering the labyrinth or by the resident macrophages reorganizing themselves through local movement to the areas of injury. Direct evidence for macrophage engulfment of apoptotic hair cells has been observed in several conditions. Here, we review evidence for phagocytosis of damaged hair cells in the sensory epithelium by tissue macrophages in the published literature and in some new experiments that are presented here as original work. Several studies also suggest that macrophages are not the only phaogocytic cells in the inner ear, but that supporting cells of the sensory epithelium also play an important role in debris clearance. We describe the various ways in which the sensory epithelia of the inner ear are adapted to eliminate damaged and dying cells. A collaborative effort between resident and migratory macrophages as well as neighboring supporting cells results in the rapid and efficient clearance of cellular debris, even in cases where hair cell loss is rapid and complete.
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DOI：
10.1007/s10162-002-3022-x
发表时间：
2003-06-01
影响因子：
2.4
作者：
Harris, JA;Cheng, AG;Rubel, EW
通讯作者：
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DOI：
10.1007/s10162-010-0231-6
发表时间：
2010-12-01
影响因子：
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DOI：
10.1073/pnas.76.1.514
发表时间：
1979-01-01
影响因子：
11.1
作者：
BOTTENSTEIN, JE;SATO, GH
通讯作者：
SATO, GH
DOI：
10.1007/s10162-014-0480-x
发表时间：
2014-12-01
影响因子：
2.4
作者：
Anttonen, Tommi;Belevich, Ilya;Pirvola, Ulla
通讯作者：
Pirvola, Ulla
影响因子：
56.9
作者：
FORGE, A;LI, L;NEVILL, G
通讯作者：
NEVILL, G