Processing Techniques and Applications of Silk Hydrogels in Bioengineering.
Processing Techniques and Applications of Silk Hydrogels in Bioengineering.
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DOI：
10.3390/jfb7030026
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发表时间：
2016-09-14
影响因子：
4.8
通讯作者：
Motta A
中科院分区：
文献类型：
--
作者：
Floren M;Migliaresi C;Motta A
水凝胶是一类颇具吸引力的可调材料平台，其结构和功能与生物环境相似，在生物工程中具有多种应用。可以使用几种天然和合成的聚合物，材料的选择基于所制备的水凝胶所需的功能特性。丝素蛋白（SF）是一种有吸引力的天然聚合物，具有优异的加工性、生物相容性、可控降解性、机械性能和可调格式，是制造水凝胶的良好候选者。人们在控制丝水凝胶的结构和功能特性方面付出了巨大的努力，将新颖的生物学特征与先进的加工技术相结合，开发下一代功能性SF水凝胶。在这里，我们回顾了为制备先进的 SF 水凝胶形式而开发的几种加工方法，强调从丝蛋白的关键结构特征及其在特定凝胶环境下的行为开始的自下而上的方法。此外，还将讨论 SF 水凝胶混合物和其他高级形式的制备。最后，我们简要描述了 SF 水凝胶在相关生物工程应用中的吸引力。
Hydrogels are an attractive class of tunable material platforms that, combined with their structural and functional likeness to biological environments, have a diversity of applications in bioengineering. Several polymers, natural and synthetic, can be used, the material selection being based on the required functional characteristics of the prepared hydrogels. Silk fibroin (SF) is an attractive natural polymer for its excellent processability, biocompatibility, controlled degradation, mechanical properties and tunable formats and a good candidate for the fabrication of hydrogels. Tremendous effort has been made to control the structural and functional characteristic of silk hydrogels, integrating novel biological features with advanced processing techniques, to develop the next generation of functional SF hydrogels. Here, we review the several processing methods developed to prepare advanced SF hydrogel formats, emphasizing a bottom-up approach beginning with critical structural characteristics of silk proteins and their behavior under specific gelation environments. Additionally, the preparation of SF hydrogel blends and other advanced formats will also be discussed. We conclude with a brief description of the attractive utility of SF hydrogels in relevant bioengineering applications.
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DOI：
10.1002/jbm.b.31686
发表时间：
2010-10
影响因子：
3.4
作者：
Chao, Pen-Hsiu Grace;Yodmuang, Supansa;Wang, Xiaoqin;Sun, Lin;Kaplan, David L.;Vunjak-Novakovic, Gordana
通讯作者：
Vunjak-Novakovic, Gordana
影响因子：
3.3
作者：
Sophia Fox AJ;Bedi A;Rodeo SA
通讯作者：
Rodeo SA
影响因子：
14
作者：
Cheng, Tzu-Yun;Chen, Ming-Hong;Wang, Tzu-Wei
通讯作者：
Wang, Tzu-Wei
影响因子：
3.4
作者：
Engler, A;Bacakova, L;Discher, D
通讯作者：
Discher, D
影响因子：
--
作者：
Gordon, TD;Schloesser, L;Spector, M
通讯作者：
Spector, M