Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics.
Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics.
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DOI：
10.1167/iovs.17-22488
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发表时间：
2018-01-01
影响因子：
4.4
通讯作者：
Sigal IA
中科院分区：
文献类型：
--
作者：
Hua Y;Voorhees AP;Sigal IA
建立视神经头(ONH)生物力学环境对眼压、脑脊液压(CSFP)和视网膜中央动脉压(BP)急性变化的敏感性模型。我们扩展了先前发表的ONH的数值模型，将代表组织解剖和机械特性、所有三种压力和视神经约束(CON)的24个因素包括在内。共研究了8340个模型，以预测因素对98个反应的影响，分两步进行：用分数因子筛选分析确定16个最具影响的因素，然后用响应面方法详细预测因素影响。影响最大的6个因素依次为：眼压、CON、巩膜模数、筛板和硬脑膜、CSFP。IOP和CSFP对ONH生物力学有不同程度的影响。CSFP对眼压的影响最大，是眼压的两倍多，对眼底巩膜旋转的影响最大。CSFP对LC拉伸和压缩的影响与巩膜和LC的弹性系数相似。在一些ONH上，CSFP引起较大的椎板后变形和蛛网膜下腔扩张。CON对LC位移有很强的影响。血压的总体影响比眼压的影响小633倍。模型预测眼压和CSFP是影响ONH生物力学的最大和第六大因素。不同的眼压和CSFP效应提示，跨层压差可能不是预测生物力学相关青光眼神经病的良好参数。CON可能会极大地影响与总ONH几何形状有关的响应，应该通过实验来确定。
To model the sensitivity of the optic nerve head (ONH) biomechanical environment to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery blood pressure (BP). We extended a previously published numerical model of the ONH to include 24 factors representing tissue anatomy and mechanical properties, all three pressures, and constraints on the optic nerve (CON). A total of 8340 models were studied to predict factor influences on 98 responses in a two-step process: a fractional factorial screening analysis to identify the 16 most influential factors, followed by a response surface methodology to predict factor effects in detail. The six most influential factors were, in order: IOP, CON, moduli of the sclera, lamina cribrosa (LC) and dura, and CSFP. IOP and CSFP affected different aspects of ONH biomechanics. The strongest influence of CSFP, more than twice that of IOP, was on the rotation of the peripapillary sclera. CSFP had similar influence on LC stretch and compression to moduli of sclera and LC. On some ONHs, CSFP caused large retrolamina deformations and subarachnoid expansion. CON had a strong influence on LC displacement. BP overall influence was 633 times smaller than that of IOP. Models predict that IOP and CSFP are the top and sixth most influential factors on ONH biomechanics. Different IOP and CSFP effects suggest that translaminar pressure difference may not be a good parameter to predict biomechanics-related glaucomatous neuropathy. CON may drastically affect the responses relating to gross ONH geometry and should be determined experimentally.
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影响因子：
4.4
作者：
Berdahl JP;Fautsch MP;Stinnett SS;Allingham RR
通讯作者：
Allingham RR
DOI：
10.1080/10255842.2015.1052417
发表时间：
2016
影响因子：
1.6
作者：
Ayyalasomayajula A;Park RI;Simon BR;Vande Geest JP
通讯作者：
Vande Geest JP
影响因子：
4.4
作者：
Balaratnasingam, Chandrakumar;Morgan, William H.;Yu, Dao-Yi
通讯作者：
Yu, Dao-Yi
影响因子：
4.4
作者：
Feola, Andrew J.;Myers, Jerry G.;Ethier, C. Ross
通讯作者：
Ethier, C. Ross
影响因子：
13.7
作者：
Berdahl, John P.;Allingham, R. Rand;Johnson, Douglas H.
通讯作者：
Johnson, Douglas H.